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Design and rationale of CATO, a Phase IIA, randomized, double-blind, placebo-controlled study of single or repeated intravenous administration of umbilical cord-derived mesenchymal stromal cells in ischemic cardiomyopathy.

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Title: Design and rationale of CATO, a Phase IIA, randomized, double-blind, placebo-controlled study of single or repeated intravenous administration of umbilical cord-derived mesenchymal stromal cells in ischemic cardiomyopathy.
Authors: Bolli R; Department of Medicine, University of Louisville, Louisville, KY. Electronic address: rbolli@louisville.edu., Tang XL; Department of Medicine, University of Louisville, Louisville, KY., Hare JM; Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL., Mitrani RD; Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL., Perin EC; Texas Heart Institute, CHI St. Luke's Health, Houston, TX., Lima JA; Department of Medicine, Johns Hopkins University, Baltimore, MD., Hurwitz BE; Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL., Kalra D; Department of Medicine, University of Louisville, Louisville, KY., Singh G; Department of Medicine, University of Louisville, Louisville, KY., Saltzman RG; Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL., Caceres LV; Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL., Nettina A; Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL., Lee YS; Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL., Bacallao K; Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL., Grant E; Biostatistics & Clinical Data Management, DP Clinical, Rockville, MD., Khan A; Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL.
Source: American heart journal [Am Heart J] 2026 Apr; Vol. 294, pp. 107328. Date of Electronic Publication: 2025 Dec 13.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: Mosby Country of Publication: United States NLM ID: 0370465 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6744 (Electronic) Linking ISSN: 00028703 NLM ISO Abbreviation: Am Heart J Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1097-6744
DOI:10.1016/j.ahj.2025.107328