Demonstration of in vivo efficacy, cryo-EM-epitope identification, and breadth of two anti-alphavirus bispecific single domain antibodies.

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Title: Demonstration of in vivo efficacy, cryo-EM-epitope identification, and breadth of two anti-alphavirus bispecific single domain antibodies.
Authors: Gardner CL; Virology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, Frederick, Maryland, USA., Pletnev S; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Liu JL; Center for Biomolecular Science and Engineering, U.S. Naval Research Laboratory, Washington, DC, USA., Anderson GP; Center for Biomolecular Science and Engineering, U.S. Naval Research Laboratory, Washington, DC, USA., Shriver-Lake LC; Center for Biomolecular Science and Engineering, U.S. Naval Research Laboratory, Washington, DC, USA., Bylund T; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Green C; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Stephens T; Vaccine Research Center Electron Microscopy Unit, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland, USA., Sutton MS; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Tsybovsky Y; Vaccine Research Center Electron Microscopy Unit, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland, USA., Roederer M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Kwong PD; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.; Aaron Diamond AIDS Research Center, Vagelos College of Physicians and Surgeons, and Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, USA., Zhou T; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Goldman ER; Center for Biomolecular Science and Engineering, U.S. Naval Research Laboratory, Washington, DC, USA., Burke CW; Virology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, Frederick, Maryland, USA.
Source: Journal of virology [J Virol] 2026 Jan 20; Vol. 100 (1), pp. e0187525. Date of Electronic Publication: 2025 Dec 16.
Publication Type: Journal Article; Research Support, N.I.H., Intramural
Journal Info: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1098-5514
DOI:10.1128/jvi.01875-25