The kinesin-4 protein KIF27 forms a cytoskeletal scaffold at the transition zone to promote motile cilia structural integrity.

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Title: The kinesin-4 protein KIF27 forms a cytoskeletal scaffold at the transition zone to promote motile cilia structural integrity.
Authors: Park H; School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China., Choi M; School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China., Zhang Y; School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China., Cheung HO; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Makino S; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Yoshikawa Y; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Qi H; School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China., Liu Z; Department of Chemistry, The University of Hong Kong, Hong Kong Special Administrative Region, China., Lan G; School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.; Center for Translational Stem Cell Biology, Hong Kong Science and Technology Park, Hong Kong Special Administrative Region, China., Fu G; School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China., Wang Q; Department of Life Science, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China., Guo SS; Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried 82152, Germany., Liu P; School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.; Center for Translational Stem Cell Biology, Hong Kong Science and Technology Park, Hong Kong Special Administrative Region, China., Liu Z; Department of Life Science, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China., Ti SC; School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China., Wang WJ; Institute of Biochemistry and Molecular Biology, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.; Materials Innovation Institute for Life Sciences and Energy, The HKU-Shenzhen Institute of Research and Innovation, Shenzhen, Guangdong 518063, China., Li XD; Department of Chemistry, The University of Hong Kong, Hong Kong Special Administrative Region, China., Ni T; School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.; Materials Innovation Institute for Life Sciences and Energy, The HKU-Shenzhen Institute of Research and Innovation, Shenzhen, Guangdong 518063, China., Hui CC; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., He M; School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Dec 23; Vol. 122 (51), pp. e2515392122. Date of Electronic Publication: 2025 Dec 16.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1091-6490
DOI:10.1073/pnas.2515392122