The kinesin-4 protein KIF27 forms a cytoskeletal scaffold at the transition zone to promote motile cilia structural integrity.

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Title: The kinesin-4 protein KIF27 forms a cytoskeletal scaffold at the transition zone to promote motile cilia structural integrity.
Authors: Park H; School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China., Choi M; School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China., Zhang Y; School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China., Cheung HO; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Makino S; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Yoshikawa Y; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Qi H; School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China., Liu Z; Department of Chemistry, The University of Hong Kong, Hong Kong Special Administrative Region, China., Lan G; School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.; Center for Translational Stem Cell Biology, Hong Kong Science and Technology Park, Hong Kong Special Administrative Region, China., Fu G; School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China., Wang Q; Department of Life Science, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China., Guo SS; Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried 82152, Germany., Liu P; School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.; Center for Translational Stem Cell Biology, Hong Kong Science and Technology Park, Hong Kong Special Administrative Region, China., Liu Z; Department of Life Science, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China., Ti SC; School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China., Wang WJ; Institute of Biochemistry and Molecular Biology, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.; Materials Innovation Institute for Life Sciences and Energy, The HKU-Shenzhen Institute of Research and Innovation, Shenzhen, Guangdong 518063, China., Li XD; Department of Chemistry, The University of Hong Kong, Hong Kong Special Administrative Region, China., Ni T; School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.; Materials Innovation Institute for Life Sciences and Energy, The HKU-Shenzhen Institute of Research and Innovation, Shenzhen, Guangdong 518063, China., Hui CC; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., He M; School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Dec 23; Vol. 122 (51), pp. e2515392122. Date of Electronic Publication: 2025 Dec 16.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: The kinesin-4 protein KIF27 forms a cytoskeletal scaffold at the transition zone to promote motile cilia structural integrity.
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  Data: <searchLink fieldCode="AU" term="%22Park+H%22">Park H</searchLink>; School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Choi+M%22">Choi M</searchLink>; School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Cheung+HO%22">Cheung HO</searchLink>; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.<br /><searchLink fieldCode="AU" term="%22Makino+S%22">Makino S</searchLink>; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.<br /><searchLink fieldCode="AU" term="%22Yoshikawa+Y%22">Yoshikawa Y</searchLink>; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.<br /><searchLink fieldCode="AU" term="%22Qi+H%22">Qi H</searchLink>; School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Liu+Z%22">Liu Z</searchLink>; Department of Chemistry, The University of Hong Kong, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Lan+G%22">Lan G</searchLink>; School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.; Center for Translational Stem Cell Biology, Hong Kong Science and Technology Park, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Fu+G%22">Fu G</searchLink>; School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Department of Life Science, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Guo+SS%22">Guo SS</searchLink>; Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried 82152, Germany.<br /><searchLink fieldCode="AU" term="%22Liu+P%22">Liu P</searchLink>; School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.; Center for Translational Stem Cell Biology, Hong Kong Science and Technology Park, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Liu+Z%22">Liu Z</searchLink>; Department of Life Science, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Ti+SC%22">Ti SC</searchLink>; School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Wang+WJ%22">Wang WJ</searchLink>; Institute of Biochemistry and Molecular Biology, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.; Materials Innovation Institute for Life Sciences and Energy, The HKU-Shenzhen Institute of Research and Innovation, Shenzhen, Guangdong 518063, China.<br /><searchLink fieldCode="AU" term="%22Li+XD%22">Li XD</searchLink>; Department of Chemistry, The University of Hong Kong, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Ni+T%22">Ni T</searchLink>; School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.; Materials Innovation Institute for Life Sciences and Energy, The HKU-Shenzhen Institute of Research and Innovation, Shenzhen, Guangdong 518063, China.<br /><searchLink fieldCode="AU" term="%22Hui+CC%22">Hui CC</searchLink>; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.<br /><searchLink fieldCode="AU" term="%22He+M%22">He M</searchLink>; School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2025 Dec 23; Vol. 122 (51), pp. e2515392122. <i>Date of Electronic Publication: </i>2025 Dec 16.
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