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TR-FRET between engineered nanobodies reveals the existence of endogenous CXCR4 oligomers.

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Title: TR-FRET between engineered nanobodies reveals the existence of endogenous CXCR4 oligomers.
Authors: Heuninck J; IGF, Univ Montpellier, CNRS, INSERM, Montpellier, France., Bobkov V; Argenx BVBA, Zwijnaarde, Belgium.; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands., Grison CM; IGF, Univ Montpellier, CNRS, INSERM, Montpellier, France., Fumagalli A; IGF, Univ Montpellier, CNRS, INSERM, Montpellier, France., Lescuyer M; IGF, Univ Montpellier, CNRS, INSERM, Montpellier, France., Otun O; IGF, Univ Montpellier, CNRS, INSERM, Montpellier, France., Bechara C; IGF, Univ Montpellier, CNRS, INSERM, Montpellier, France., Lamarque L; Revvity, Parc Marcel Boiteux-BP 84175, Codolet, France., Trinquet E; Revvity, Parc Marcel Boiteux-BP 84175, Codolet, France., Bachelerie F; Inserm UMR996-Inflammation, microbiome and immunosurveillance, Université Paris-Saclay, Clamart, France., Marin P; IGF, Univ Montpellier, CNRS, INSERM, Montpellier, France., Mouillac B; IGF, Univ Montpellier, CNRS, INSERM, Montpellier, France., Granier S; IGF, Univ Montpellier, CNRS, INSERM, Montpellier, France., van der Woning B; Argenx BVBA, Zwijnaarde, Belgium., de Haard H; Argenx BVBA, Zwijnaarde, Belgium., Smit MJ; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands., Heukers R; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands. r.heukers@vu.nl.; QVQ Holding BV, Utrecht, The Netherlands. r.heukers@vu.nl., Durroux T; IGF, Univ Montpellier, CNRS, INSERM, Montpellier, France. thierry.durroux@igf.cnrs.fr.
Source: Communications biology [Commun Biol] 2025 Dec 16; Vol. 8 (1), pp. 1777. Date of Electronic Publication: 2025 Dec 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2399-3642
DOI:10.1038/s42003-025-09166-6