Orthosteric Molecular Glue Inhibits COP9 Signalosome with Substrate-Dependent Potency.

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Bibliographic Details
Title: Orthosteric Molecular Glue Inhibits COP9 Signalosome with Substrate-Dependent Potency.
Authors: Shi H; Department of Pharmacology, Box 357280, University of Washington, Seattle, WA 98195, USA., Wang X; Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA., Yu C; Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA., Mao H; Department of Pharmacology, Box 357280, University of Washington, Seattle, WA 98195, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA., Jiao F; Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA., Braitbard M; The Rachel and Selim Benin School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel., Shor B; The Rachel and Selim Benin School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel., Zhang Z; Department of Biochemistry, University of Washington, Seattle, WA 98175, USA., Hinds TR; Department of Pharmacology, Box 357280, University of Washington, Seattle, WA 98195, USA., Cao S; Department of Pharmacology, Box 357280, University of Washington, Seattle, WA 98195, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA., Fan E; Department of Biochemistry, University of Washington, Seattle, WA 98175, USA., Schneidman-Duhovny D; The Rachel and Selim Benin School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel., Huang L; Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA., Zheng N; Department of Pharmacology, Box 357280, University of Washington, Seattle, WA 98195, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Nov 30. Date of Electronic Publication: 2025 Nov 30.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.1101/2025.11.26.690573