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Orthosteric Molecular Glue Inhibits COP9 Signalosome with Substrate-Dependent Potency.

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Title: Orthosteric Molecular Glue Inhibits COP9 Signalosome with Substrate-Dependent Potency.
Authors: Shi H; Department of Pharmacology, Box 357280, University of Washington, Seattle, WA 98195, USA., Wang X; Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA., Yu C; Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA., Mao H; Department of Pharmacology, Box 357280, University of Washington, Seattle, WA 98195, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA., Jiao F; Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA., Braitbard M; The Rachel and Selim Benin School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel., Shor B; The Rachel and Selim Benin School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel., Zhang Z; Department of Biochemistry, University of Washington, Seattle, WA 98175, USA., Hinds TR; Department of Pharmacology, Box 357280, University of Washington, Seattle, WA 98195, USA., Cao S; Department of Pharmacology, Box 357280, University of Washington, Seattle, WA 98195, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA., Fan E; Department of Biochemistry, University of Washington, Seattle, WA 98175, USA., Schneidman-Duhovny D; The Rachel and Selim Benin School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel., Huang L; Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA., Zheng N; Department of Pharmacology, Box 357280, University of Washington, Seattle, WA 98195, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Nov 30. Date of Electronic Publication: 2025 Nov 30.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Orthosteric Molecular Glue Inhibits COP9 Signalosome with Substrate-Dependent Potency.
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  Data: <searchLink fieldCode="AU" term="%22Shi+H%22">Shi H</searchLink>; Department of Pharmacology, Box 357280, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA.<br /><searchLink fieldCode="AU" term="%22Yu+C%22">Yu C</searchLink>; Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA.<br /><searchLink fieldCode="AU" term="%22Mao+H%22">Mao H</searchLink>; Department of Pharmacology, Box 357280, University of Washington, Seattle, WA 98195, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Jiao+F%22">Jiao F</searchLink>; Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA.<br /><searchLink fieldCode="AU" term="%22Braitbard+M%22">Braitbard M</searchLink>; The Rachel and Selim Benin School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Shor+B%22">Shor B</searchLink>; The Rachel and Selim Benin School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA 98175, USA.<br /><searchLink fieldCode="AU" term="%22Hinds+TR%22">Hinds TR</searchLink>; Department of Pharmacology, Box 357280, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Cao+S%22">Cao S</searchLink>; Department of Pharmacology, Box 357280, University of Washington, Seattle, WA 98195, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Fan+E%22">Fan E</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA 98175, USA.<br /><searchLink fieldCode="AU" term="%22Schneidman-Duhovny+D%22">Schneidman-Duhovny D</searchLink>; The Rachel and Selim Benin School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Huang+L%22">Huang L</searchLink>; Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA.<br /><searchLink fieldCode="AU" term="%22Zheng+N%22">Zheng N</searchLink>; Department of Pharmacology, Box 357280, University of Washington, Seattle, WA 98195, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.
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