Reprogramming M2b Macrophages via GPX1 Activation by Selenium Nanoparticles Attenuates Lupus Nephritis.

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Title: Reprogramming M2b Macrophages via GPX1 Activation by Selenium Nanoparticles Attenuates Lupus Nephritis.
Authors: Lv H; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 518000, China.; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Sun Yat-sen University, Guangzhou, 518000, China.; Department of Nephrology, Jieyang People's Hospital, Jieyang, China., Huang G; State Key Laboratory of Bioactive Molecules and Druggability Assessment, MOE Key Laboratory of Tumor Molecular Biology, Department of Chemistry, Jinan University, Guangzhou, China., Li H; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 518000, China.; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Sun Yat-sen University, Guangzhou, 518000, China.; Department of Nephrology, Jieyang People's Hospital, Jieyang, China., Liang H; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 518000, China.; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Sun Yat-sen University, Guangzhou, 518000, China.; Department of Nephrology, Jieyang People's Hospital, Jieyang, China., Peng H; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 518000, China.; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Sun Yat-sen University, Guangzhou, 518000, China., Wu K; Department of Nephrology, Jieyang People's Hospital, Jieyang, China., Chen W; Department of Pathology, The First Affiliated Hospital, Sun Yatsen University, Guangzhou, 518000, China., Zhang D; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 518000, China.; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Sun Yat-sen University, Guangzhou, 518000, China., Ma K; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 518000, China.; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Sun Yat-sen University, Guangzhou, 518000, China., Du Y; Basic and Translational Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 518000, China., Luo S; Basic and Translational Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 518000, China., Zhou Y; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 518000, China.; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Sun Yat-sen University, Guangzhou, 518000, China., Mao H; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 518000, China.; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Sun Yat-sen University, Guangzhou, 518000, China., Chen W; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 518000, China.; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Sun Yat-sen University, Guangzhou, 518000, China., Chen T; State Key Laboratory of Bioactive Molecules and Druggability Assessment, MOE Key Laboratory of Tumor Molecular Biology, Department of Chemistry, Jinan University, Guangzhou, China., Zhou Y; Basic and Translational Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 518000, China., Liu Q; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 518000, China.; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Sun Yat-sen University, Guangzhou, 518000, China.; Department of Nephrology, Jieyang People's Hospital, Jieyang, China.
Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2026 Feb; Vol. 13 (12), pp. e19981. Date of Electronic Publication: 2025 Dec 17.
Publication Type: Journal Article
Journal Info: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2198-3844
DOI:10.1002/advs.202519981