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Reprogramming M2b Macrophages via GPX1 Activation by Selenium Nanoparticles Attenuates Lupus Nephritis.

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Title: Reprogramming M2b Macrophages via GPX1 Activation by Selenium Nanoparticles Attenuates Lupus Nephritis.
Authors: Lv H; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 518000, China.; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Sun Yat-sen University, Guangzhou, 518000, China.; Department of Nephrology, Jieyang People's Hospital, Jieyang, China., Huang G; State Key Laboratory of Bioactive Molecules and Druggability Assessment, MOE Key Laboratory of Tumor Molecular Biology, Department of Chemistry, Jinan University, Guangzhou, China., Li H; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 518000, China.; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Sun Yat-sen University, Guangzhou, 518000, China.; Department of Nephrology, Jieyang People's Hospital, Jieyang, China., Liang H; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 518000, China.; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Sun Yat-sen University, Guangzhou, 518000, China.; Department of Nephrology, Jieyang People's Hospital, Jieyang, China., Peng H; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 518000, China.; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Sun Yat-sen University, Guangzhou, 518000, China., Wu K; Department of Nephrology, Jieyang People's Hospital, Jieyang, China., Chen W; Department of Pathology, The First Affiliated Hospital, Sun Yatsen University, Guangzhou, 518000, China., Zhang D; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 518000, China.; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Sun Yat-sen University, Guangzhou, 518000, China., Ma K; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 518000, China.; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Sun Yat-sen University, Guangzhou, 518000, China., Du Y; Basic and Translational Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 518000, China., Luo S; Basic and Translational Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 518000, China., Zhou Y; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 518000, China.; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Sun Yat-sen University, Guangzhou, 518000, China., Mao H; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 518000, China.; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Sun Yat-sen University, Guangzhou, 518000, China., Chen W; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 518000, China.; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Sun Yat-sen University, Guangzhou, 518000, China., Chen T; State Key Laboratory of Bioactive Molecules and Druggability Assessment, MOE Key Laboratory of Tumor Molecular Biology, Department of Chemistry, Jinan University, Guangzhou, China., Zhou Y; Basic and Translational Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 518000, China., Liu Q; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 518000, China.; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Sun Yat-sen University, Guangzhou, 518000, China.; Department of Nephrology, Jieyang People's Hospital, Jieyang, China.
Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2026 Feb; Vol. 13 (12), pp. e19981. Date of Electronic Publication: 2025 Dec 17.
Publication Type: Journal Article
Journal Info: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE
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  Data: Reprogramming M2b Macrophages via GPX1 Activation by Selenium Nanoparticles Attenuates Lupus Nephritis.
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  Data: <searchLink fieldCode="AU" term="%22Lv+H%22">Lv H</searchLink>; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 518000, China.; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Sun Yat-sen University, Guangzhou, 518000, China.; Department of Nephrology, Jieyang People's Hospital, Jieyang, China.<br /><searchLink fieldCode="AU" term="%22Huang+G%22">Huang G</searchLink>; State Key Laboratory of Bioactive Molecules and Druggability Assessment, MOE Key Laboratory of Tumor Molecular Biology, Department of Chemistry, Jinan University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 518000, China.; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Sun Yat-sen University, Guangzhou, 518000, China.; Department of Nephrology, Jieyang People's Hospital, Jieyang, China.<br /><searchLink fieldCode="AU" term="%22Liang+H%22">Liang H</searchLink>; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 518000, China.; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Sun Yat-sen University, Guangzhou, 518000, China.; Department of Nephrology, Jieyang People's Hospital, Jieyang, China.<br /><searchLink fieldCode="AU" term="%22Peng+H%22">Peng H</searchLink>; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 518000, China.; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Sun Yat-sen University, Guangzhou, 518000, China.<br /><searchLink fieldCode="AU" term="%22Wu+K%22">Wu K</searchLink>; Department of Nephrology, Jieyang People's Hospital, Jieyang, China.<br /><searchLink fieldCode="AU" term="%22Chen+W%22">Chen W</searchLink>; Department of Pathology, The First Affiliated Hospital, Sun Yatsen University, Guangzhou, 518000, China.<br /><searchLink fieldCode="AU" term="%22Zhang+D%22">Zhang D</searchLink>; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 518000, China.; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Sun Yat-sen University, Guangzhou, 518000, China.<br /><searchLink fieldCode="AU" term="%22Ma+K%22">Ma K</searchLink>; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 518000, China.; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Sun Yat-sen University, Guangzhou, 518000, China.<br /><searchLink fieldCode="AU" term="%22Du+Y%22">Du Y</searchLink>; Basic and Translational Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 518000, China.<br /><searchLink fieldCode="AU" term="%22Luo+S%22">Luo S</searchLink>; Basic and Translational Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 518000, China.<br /><searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 518000, China.; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Sun Yat-sen University, Guangzhou, 518000, China.<br /><searchLink fieldCode="AU" term="%22Mao+H%22">Mao H</searchLink>; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 518000, China.; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Sun Yat-sen University, Guangzhou, 518000, China.<br /><searchLink fieldCode="AU" term="%22Chen+W%22">Chen W</searchLink>; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 518000, China.; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Sun Yat-sen University, Guangzhou, 518000, China.<br /><searchLink fieldCode="AU" term="%22Chen+T%22">Chen T</searchLink>; State Key Laboratory of Bioactive Molecules and Druggability Assessment, MOE Key Laboratory of Tumor Molecular Biology, Department of Chemistry, Jinan University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; Basic and Translational Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 518000, China.<br /><searchLink fieldCode="AU" term="%22Liu+Q%22">Liu Q</searchLink>; Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 518000, China.; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Sun Yat-sen University, Guangzhou, 518000, China.; Department of Nephrology, Jieyang People's Hospital, Jieyang, China.
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