Can we Save the rectum by watchful waiting or transanal microsurgery following shorT-course radiotherapy and Additional local oR systemic Treatment for early-stage REctal Cancer? STARTREC-3 protocol for a non-randomised, multicentre, phase II platform study.

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Title: Can we Save the rectum by watchful waiting or transanal microsurgery following shorT-course radiotherapy and Additional local oR systemic Treatment for early-stage REctal Cancer? STARTREC-3 protocol for a non-randomised, multicentre, phase II platform study.
Authors: de Vries SEN; Department of Surgery, Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands., Couwenberg AM; Department of Radiotherapy, Netherlands Cancer Institute, Amsterdam, The Netherlands., Marijnen CAM; Department of Radiotherapy, Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Radiotherapy, LUMC, Leiden, The Netherlands., Beets GL; Department of Surgery, Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Surgery, Maastricht University Medical Centre+, Maastricht, The Netherlands., Burger JW; Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands., Chalabi M; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands., de Groot JW; Department of Medical Oncology, Isala Hospital, Zwolle, The Netherlands., Intven M; Department of Radiotherapy, University Medical Centre Utrecht, Utrecht, The Netherlands., Peulen HM; Department of Radiotherapy, Catharina Hospital, Eindhoven, The Netherlands., Roodhart JML; Department of Medical Oncology, University Medical Centre Utrecht, Utrecht, The Netherlands., de Wilt JHW; Department of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands., Grotenhuis BA; Department of Surgery, Netherlands Cancer Institute, Amsterdam, The Netherlands b.grotenhuis@nki.nl.
Source: BMJ open [BMJ Open] 2025 Dec 17; Vol. 15 (12), pp. e111711. Date of Electronic Publication: 2025 Dec 17.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2044-6055
DOI:10.1136/bmjopen-2025-111711