The pathogenesis of therapy-related myeloid neoplasms from TP53-mutant clonal hematopoiesis.

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Title: The pathogenesis of therapy-related myeloid neoplasms from TP53-mutant clonal hematopoiesis.
Authors: Fullin J; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Zurich, Switzerland., Topçu E; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Zurich, Switzerland., Zielińska KA; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Zurich, Switzerland., Schimmer RR; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Zurich, Switzerland., Klemm N; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Zurich, Switzerland., Koch C; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Zurich, Switzerland., Caiado F; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Zurich, Switzerland., Lock M; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Zurich, Switzerland., Doerdelmann C; Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland., Bühler MM; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland., Tchinda J; Laboratory for Oncology, Children's Hospital Zurich, Zurich, Switzerland., Kurppa KJ; Institute of Biomedicine and Medicity Research Laboratories, University of Turku, Turku, Finland., Borsig L; Department of Physiology, University of Zurich, Zurich, Switzerland., Jones PH; Wellcome Sanger Institute, Hinxton, UK.; Department of Oncology, University of Cambridge, Hutchinson Research Centre, Cambridge Biomedical Campus, Cambridge, UK., Lopes M; Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland., Manz MG; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Zurich, Switzerland.; Comprehensive Cancer Center Zurich, Zurich, Switzerland., Boettcher S; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Zurich, Switzerland. steffen.boettcher@usz.ch.; Comprehensive Cancer Center Zurich, Zurich, Switzerland. steffen.boettcher@usz.ch.
Source: Leukemia [Leukemia] 2026 Feb; Vol. 40 (2), pp. 279-292. Date of Electronic Publication: 2025 Dec 17.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5551
DOI:10.1038/s41375-025-02839-5