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Multi-omics analysis reveals cell adhesion molecules as key regulators of immune cell infiltration and adverse outcomes and in vitro validation of CLDN16 in pancreatic adenocarcinoma.

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Title: Multi-omics analysis reveals cell adhesion molecules as key regulators of immune cell infiltration and adverse outcomes and in vitro validation of CLDN16 in pancreatic adenocarcinoma.
Authors: Zhuo Z; Shunde Women and Children's Hospital of Guangdong Medical University, Foshan, 528300, Guangdong, China.; Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, Guangdong, China., Luo J; Shunde Women and Children's Hospital of Guangdong Medical University, Foshan, 528300, Guangdong, China., Liang G; Shunde Women and Children's Hospital of Guangdong Medical University, Foshan, 528300, Guangdong, China., Li J; Shunde Women and Children's Hospital of Guangdong Medical University, Foshan, 528300, Guangdong, China., Yang Q; Shunde Women and Children's Hospital of Guangdong Medical University, Foshan, 528300, Guangdong, China. Yangqi5056@163.com.; Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, Guangdong, China. Yangqi5056@163.com., Huang L; Shunde Women and Children's Hospital of Guangdong Medical University, Foshan, 528300, Guangdong, China. huang0zuibang@163.com.
Source: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2025 Dec 18; Vol. 83 (1). Date of Electronic Publication: 2025 Dec 18.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1420-9071
DOI:10.1007/s00018-025-06009-9