Tumor-secreted clusterin promotes cachectic fat wasting via disrupting circadian gene expression and adipogenesis.
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| Title: | Tumor-secreted clusterin promotes cachectic fat wasting via disrupting circadian gene expression and adipogenesis. |
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| Authors: | Liu Y; Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, P. R. China. llliuyan@sina.com.; Department of Biochemistry, School of Life Sciences, Nanjing Normal University, Nanjing, 210023, P. R. China. llliuyan@sina.com., Zhou Y; Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, 215000, P. R. China., Zhang M; Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, P. R. China.; Department of Biochemistry, School of Life Sciences, Nanjing Normal University, Nanjing, 210023, P. R. China., Zhang J; Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, P. R. China.; Department of Biochemistry, School of Life Sciences, Nanjing Normal University, Nanjing, 210023, P. R. China., Chen J; Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, P. R. China.; Department of Biochemistry, School of Life Sciences, Nanjing Normal University, Nanjing, 210023, P. R. China., Chen L; Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, P. R. China.; Department of Biochemistry, School of Life Sciences, Nanjing Normal University, Nanjing, 210023, P. R. China., Tian J; Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, P. R. China.; Department of Biochemistry, School of Life Sciences, Nanjing Normal University, Nanjing, 210023, P. R. China., Lv X; Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, P. R. China.; Department of Biochemistry, School of Life Sciences, Nanjing Normal University, Nanjing, 210023, P. R. China., Ma X; Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, P. R. China., Xu J; Department of Clinical Laboratory, Zhongda Hospital Southeast University, Nanjing, 210009, P.R. China., Shi J; Department of Thoracic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210000, China., Chen L; Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, P. R. China. chenliming1981@u.nus.edu.; Jiangsu Key Laboratory of Innovative Cancer Diagnosis & Therapeutics, Cancer Institute of Jiangsu Province, Nanjing, 210009, P. R. China. chenliming1981@u.nus.edu.; The Fourth Clinical College of Nanjing Medical University, Nanjing, 210009, P. R. China. chenliming1981@u.nus.edu. |
| Source: | The EMBO journal [EMBO J] 2026 Feb; Vol. 45 (3), pp. 856-878. Date of Electronic Publication: 2025 Dec 17. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1460-2075 |
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| DOI: | 10.1038/s44318-025-00661-4 |
