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Tumor-secreted clusterin promotes cachectic fat wasting via disrupting circadian gene expression and adipogenesis.

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Title: Tumor-secreted clusterin promotes cachectic fat wasting via disrupting circadian gene expression and adipogenesis.
Authors: Liu Y; Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, P. R. China. llliuyan@sina.com.; Department of Biochemistry, School of Life Sciences, Nanjing Normal University, Nanjing, 210023, P. R. China. llliuyan@sina.com., Zhou Y; Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, 215000, P. R. China., Zhang M; Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, P. R. China.; Department of Biochemistry, School of Life Sciences, Nanjing Normal University, Nanjing, 210023, P. R. China., Zhang J; Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, P. R. China.; Department of Biochemistry, School of Life Sciences, Nanjing Normal University, Nanjing, 210023, P. R. China., Chen J; Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, P. R. China.; Department of Biochemistry, School of Life Sciences, Nanjing Normal University, Nanjing, 210023, P. R. China., Chen L; Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, P. R. China.; Department of Biochemistry, School of Life Sciences, Nanjing Normal University, Nanjing, 210023, P. R. China., Tian J; Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, P. R. China.; Department of Biochemistry, School of Life Sciences, Nanjing Normal University, Nanjing, 210023, P. R. China., Lv X; Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, P. R. China.; Department of Biochemistry, School of Life Sciences, Nanjing Normal University, Nanjing, 210023, P. R. China., Ma X; Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, P. R. China., Xu J; Department of Clinical Laboratory, Zhongda Hospital Southeast University, Nanjing, 210009, P.R. China., Shi J; Department of Thoracic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210000, China., Chen L; Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, P. R. China. chenliming1981@u.nus.edu.; Jiangsu Key Laboratory of Innovative Cancer Diagnosis & Therapeutics, Cancer Institute of Jiangsu Province, Nanjing, 210009, P. R. China. chenliming1981@u.nus.edu.; The Fourth Clinical College of Nanjing Medical University, Nanjing, 210009, P. R. China. chenliming1981@u.nus.edu.
Source: The EMBO journal [EMBO J] 2026 Feb; Vol. 45 (3), pp. 856-878. Date of Electronic Publication: 2025 Dec 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Tumor-secreted clusterin promotes cachectic fat wasting via disrupting circadian gene expression and adipogenesis.
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  Data: <searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, P. R. China. llliuyan@sina.com.; Department of Biochemistry, School of Life Sciences, Nanjing Normal University, Nanjing, 210023, P. R. China. llliuyan@sina.com.<br /><searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, 215000, P. R. China.<br /><searchLink fieldCode="AU" term="%22Zhang+M%22">Zhang M</searchLink>; Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, P. R. China.; Department of Biochemistry, School of Life Sciences, Nanjing Normal University, Nanjing, 210023, P. R. China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, P. R. China.; Department of Biochemistry, School of Life Sciences, Nanjing Normal University, Nanjing, 210023, P. R. China.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, P. R. China.; Department of Biochemistry, School of Life Sciences, Nanjing Normal University, Nanjing, 210023, P. R. China.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, P. R. China.; Department of Biochemistry, School of Life Sciences, Nanjing Normal University, Nanjing, 210023, P. R. China.<br /><searchLink fieldCode="AU" term="%22Tian+J%22">Tian J</searchLink>; Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, P. R. China.; Department of Biochemistry, School of Life Sciences, Nanjing Normal University, Nanjing, 210023, P. R. China.<br /><searchLink fieldCode="AU" term="%22Lv+X%22">Lv X</searchLink>; Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, P. R. China.; Department of Biochemistry, School of Life Sciences, Nanjing Normal University, Nanjing, 210023, P. R. China.<br /><searchLink fieldCode="AU" term="%22Ma+X%22">Ma X</searchLink>; Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, P. R. China.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; Department of Clinical Laboratory, Zhongda Hospital Southeast University, Nanjing, 210009, P.R. China.<br /><searchLink fieldCode="AU" term="%22Shi+J%22">Shi J</searchLink>; Department of Thoracic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210000, China.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, 210009, P. R. China. chenliming1981@u.nus.edu.; Jiangsu Key Laboratory of Innovative Cancer Diagnosis & Therapeutics, Cancer Institute of Jiangsu Province, Nanjing, 210009, P. R. China. chenliming1981@u.nus.edu.; The Fourth Clinical College of Nanjing Medical University, Nanjing, 210009, P. R. China. chenliming1981@u.nus.edu.
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  Data: <searchLink fieldCode="JN" term="%228208664%22">The EMBO journal</searchLink> [EMBO J] 2026 Feb; Vol. 45 (3), pp. 856-878. <i>Date of Electronic Publication: </i>2025 Dec 17.
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