Kynurenic acid signaling expands in human and nonhuman primates and impairs dorsolateral prefrontal cortical cognition that is key to mental illness.

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Title: Kynurenic acid signaling expands in human and nonhuman primates and impairs dorsolateral prefrontal cortical cognition that is key to mental illness.
Authors: Yang S; Department of Neuroscience Yale Medical School, New Haven, CT, USA., Datta D; Department of Neuroscience Yale Medical School, New Haven, CT, USA.; Department of Psychiatry, Yale Medical School, New Haven, CT, USA., Krienen FM; Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA., Woo E; Department of Neuroscience Yale Medical School, New Haven, CT, USA., May A; Department of Neuroscience Yale Medical School, New Haven, CT, USA., Anderson GM; Department of Child Psychiatry, Yale Medical School, New Haven, CT, USA., Galvin VC; Department of Neuroscience Yale Medical School, New Haven, CT, USA., Gonzalez-Burgos G; Departments of Psychiatry and Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA., Lewis DA; Departments of Psychiatry and Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA., Ling E; Department of Genetics, Harvard Medical School, Boston, MA, USA., McCarroll SA; Department of Genetics, Harvard Medical School, Boston, MA, USA., Arnsten AF; Department of Neuroscience Yale Medical School, New Haven, CT, USA., Wang M; Department of Neuroscience Yale Medical School, New Haven, CT, USA. min.wang@yale.edu.
Source: Molecular psychiatry [Mol Psychiatry] 2026 Feb; Vol. 31 (2), pp. 1190-1200.
Publication Type: Journal Article; News
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5578
DOI:10.1038/s41380-025-03425-y