High-throughput in silico screen uncovers key regulators of 3D genome architecture.

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Title: High-throughput in silico screen uncovers key regulators of 3D genome architecture.
Authors: Bai J; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Lyu Q; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Tan J; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY, USA.; Department of Medicine and Division of Precision Medicine, NYU Grossman School of Medicine, New York, NY, USA., Issner R; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA., Tischer B; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA., Liu H; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Neurobiology, Harvard Medical School, Boston, MA, USA.; Society of Fellows, Harvard University, Cambridge, MA, USA., Goel V; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Biological Engineering and Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Ling X; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY, USA., Bernstein BE; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Cancer Biology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA., Tsirigos A; Department of Medicine and Division of Precision Medicine, NYU Grossman School of Medicine, New York, NY, USA., Hansen AS; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Biological Engineering and Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Xia B; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY, USA.; Society of Fellows, Harvard University, Cambridge, MA, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Dec 11. Date of Electronic Publication: 2025 Dec 11.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.64898/2025.12.09.693120