Cell-surface RNA forms ternary complex with RNA-binding proteins and heparan sulfate to recruit immune receptors.

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Title: Cell-surface RNA forms ternary complex with RNA-binding proteins and heparan sulfate to recruit immune receptors.
Authors: Li Z; Human Genetics Department, Leiden University Medical Centre, 2333 ZC Leiden, the Netherlands; Department of BioNanoScience, Kavli Institute of Nanoscience Delft, Delft University of Technology, 2629 HZ Delft, the Netherlands. Electronic address: z.li@uu.nl., Joshi BS; Department of BioNanoScience, Kavli Institute of Nanoscience Delft, Delft University of Technology, 2629 HZ Delft, the Netherlands., Yin H; Human Genetics Department, Leiden University Medical Centre, 2333 ZC Leiden, the Netherlands; Division of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, the Netherlands., Wijdeven RH; Department of Cell and Chemical Biology, Oncode Institute, Leiden University Medical Center, 2333 ZA Leiden, Zuid-Holland, the Netherlands., Koç A; Human Genetics Department, Leiden University Medical Centre, 2333 ZC Leiden, the Netherlands; Division of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, the Netherlands., Zijlmans DW; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences (RIMLS), Oncode Institute, Radboud University Nijmegen, Nijmegen 6525 GA, the Netherlands., Santos-Barriopedro I; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences (RIMLS), Oncode Institute, Radboud University Nijmegen, Nijmegen 6525 GA, the Netherlands., Mei H; Sequencing Analysis Support Core, Department of Biomedical Data Sciences, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, the Netherlands., Wu W; Human Genetics Department, Leiden University Medical Centre, 2333 ZC Leiden, the Netherlands; Division of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, the Netherlands., Shademan M; Human Genetics Department, Leiden University Medical Centre, 2333 ZC Leiden, the Netherlands., Zawisza FM; Human Genetics Department, Leiden University Medical Centre, 2333 ZC Leiden, the Netherlands; Division of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, the Netherlands., Bos E; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands., Chopra P; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA., Tanenbaum ME; Department of BioNanoScience, Kavli Institute of Nanoscience Delft, Delft University of Technology, 2629 HZ Delft, the Netherlands; Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands., Sharp TH; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands; School of Biochemistry, University of Bristol, Bristol BS8 1TD, UK., Vermeulen M; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences (RIMLS), Oncode Institute, Radboud University Nijmegen, Nijmegen 6525 GA, the Netherlands; Division of Molecular Genetics, Netherlands Cancer Institute, Amsterdam 1066 CX, the Netherlands., Raz V; Human Genetics Department, Leiden University Medical Centre, 2333 ZC Leiden, the Netherlands. Electronic address: v.raz@lumc.nl., Joo C; Department of BioNanoScience, Kavli Institute of Nanoscience Delft, Delft University of Technology, 2629 HZ Delft, the Netherlands; Department of Physics, Ewha Woman's University, Seoul 03760, Republic of Korea. Electronic address: c.joo@tudelft.nl.
Source: Molecular cell [Mol Cell] 2025 Dec 18; Vol. 85 (24), pp. 4633-4650.e11.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1097-4164
DOI:10.1016/j.molcel.2025.11.020