Cell-surface RNA forms ternary complex with RNA-binding proteins and heparan sulfate to recruit immune receptors.

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Title: Cell-surface RNA forms ternary complex with RNA-binding proteins and heparan sulfate to recruit immune receptors.
Authors: Li Z; Human Genetics Department, Leiden University Medical Centre, 2333 ZC Leiden, the Netherlands; Department of BioNanoScience, Kavli Institute of Nanoscience Delft, Delft University of Technology, 2629 HZ Delft, the Netherlands. Electronic address: z.li@uu.nl., Joshi BS; Department of BioNanoScience, Kavli Institute of Nanoscience Delft, Delft University of Technology, 2629 HZ Delft, the Netherlands., Yin H; Human Genetics Department, Leiden University Medical Centre, 2333 ZC Leiden, the Netherlands; Division of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, the Netherlands., Wijdeven RH; Department of Cell and Chemical Biology, Oncode Institute, Leiden University Medical Center, 2333 ZA Leiden, Zuid-Holland, the Netherlands., Koç A; Human Genetics Department, Leiden University Medical Centre, 2333 ZC Leiden, the Netherlands; Division of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, the Netherlands., Zijlmans DW; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences (RIMLS), Oncode Institute, Radboud University Nijmegen, Nijmegen 6525 GA, the Netherlands., Santos-Barriopedro I; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences (RIMLS), Oncode Institute, Radboud University Nijmegen, Nijmegen 6525 GA, the Netherlands., Mei H; Sequencing Analysis Support Core, Department of Biomedical Data Sciences, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, the Netherlands., Wu W; Human Genetics Department, Leiden University Medical Centre, 2333 ZC Leiden, the Netherlands; Division of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, the Netherlands., Shademan M; Human Genetics Department, Leiden University Medical Centre, 2333 ZC Leiden, the Netherlands., Zawisza FM; Human Genetics Department, Leiden University Medical Centre, 2333 ZC Leiden, the Netherlands; Division of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, the Netherlands., Bos E; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands., Chopra P; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA., Tanenbaum ME; Department of BioNanoScience, Kavli Institute of Nanoscience Delft, Delft University of Technology, 2629 HZ Delft, the Netherlands; Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands., Sharp TH; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands; School of Biochemistry, University of Bristol, Bristol BS8 1TD, UK., Vermeulen M; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences (RIMLS), Oncode Institute, Radboud University Nijmegen, Nijmegen 6525 GA, the Netherlands; Division of Molecular Genetics, Netherlands Cancer Institute, Amsterdam 1066 CX, the Netherlands., Raz V; Human Genetics Department, Leiden University Medical Centre, 2333 ZC Leiden, the Netherlands. Electronic address: v.raz@lumc.nl., Joo C; Department of BioNanoScience, Kavli Institute of Nanoscience Delft, Delft University of Technology, 2629 HZ Delft, the Netherlands; Department of Physics, Ewha Woman's University, Seoul 03760, Republic of Korea. Electronic address: c.joo@tudelft.nl.
Source: Molecular cell [Mol Cell] 2025 Dec 18; Vol. 85 (24), pp. 4633-4650.e11.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE
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  Data: Cell-surface RNA forms ternary complex with RNA-binding proteins and heparan sulfate to recruit immune receptors.
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  Data: <searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Human Genetics Department, Leiden University Medical Centre, 2333 ZC Leiden, the Netherlands; Department of BioNanoScience, Kavli Institute of Nanoscience Delft, Delft University of Technology, 2629 HZ Delft, the Netherlands. Electronic address: z.li@uu.nl.<br /><searchLink fieldCode="AU" term="%22Joshi+BS%22">Joshi BS</searchLink>; Department of BioNanoScience, Kavli Institute of Nanoscience Delft, Delft University of Technology, 2629 HZ Delft, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Yin+H%22">Yin H</searchLink>; Human Genetics Department, Leiden University Medical Centre, 2333 ZC Leiden, the Netherlands; Division of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Wijdeven+RH%22">Wijdeven RH</searchLink>; Department of Cell and Chemical Biology, Oncode Institute, Leiden University Medical Center, 2333 ZA Leiden, Zuid-Holland, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Koç+A%22">Koç A</searchLink>; Human Genetics Department, Leiden University Medical Centre, 2333 ZC Leiden, the Netherlands; Division of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Zijlmans+DW%22">Zijlmans DW</searchLink>; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences (RIMLS), Oncode Institute, Radboud University Nijmegen, Nijmegen 6525 GA, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Santos-Barriopedro+I%22">Santos-Barriopedro I</searchLink>; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences (RIMLS), Oncode Institute, Radboud University Nijmegen, Nijmegen 6525 GA, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Mei+H%22">Mei H</searchLink>; Sequencing Analysis Support Core, Department of Biomedical Data Sciences, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Wu+W%22">Wu W</searchLink>; Human Genetics Department, Leiden University Medical Centre, 2333 ZC Leiden, the Netherlands; Division of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Shademan+M%22">Shademan M</searchLink>; Human Genetics Department, Leiden University Medical Centre, 2333 ZC Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Zawisza+FM%22">Zawisza FM</searchLink>; Human Genetics Department, Leiden University Medical Centre, 2333 ZC Leiden, the Netherlands; Division of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bos+E%22">Bos E</searchLink>; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Chopra+P%22">Chopra P</searchLink>; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.<br /><searchLink fieldCode="AU" term="%22Tanenbaum+ME%22">Tanenbaum ME</searchLink>; Department of BioNanoScience, Kavli Institute of Nanoscience Delft, Delft University of Technology, 2629 HZ Delft, the Netherlands; Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Sharp+TH%22">Sharp TH</searchLink>; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands; School of Biochemistry, University of Bristol, Bristol BS8 1TD, UK.<br /><searchLink fieldCode="AU" term="%22Vermeulen+M%22">Vermeulen M</searchLink>; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences (RIMLS), Oncode Institute, Radboud University Nijmegen, Nijmegen 6525 GA, the Netherlands; Division of Molecular Genetics, Netherlands Cancer Institute, Amsterdam 1066 CX, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Raz+V%22">Raz V</searchLink>; Human Genetics Department, Leiden University Medical Centre, 2333 ZC Leiden, the Netherlands. Electronic address: v.raz@lumc.nl.<br /><searchLink fieldCode="AU" term="%22Joo+C%22">Joo C</searchLink>; Department of BioNanoScience, Kavli Institute of Nanoscience Delft, Delft University of Technology, 2629 HZ Delft, the Netherlands; Department of Physics, Ewha Woman's University, Seoul 03760, Republic of Korea. Electronic address: c.joo@tudelft.nl.
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