Thrombopoietin increases susceptibility for EVI1 + KMT2A-MLLT3-driven AML expressing stem cell genes linked to poor outcome.

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Title: Thrombopoietin increases susceptibility for EVI1 + KMT2A-MLLT3-driven AML expressing stem cell genes linked to poor outcome.
Authors: Châtel-Soulet HÉ; University Children's Hospital & Department of Biomedicine, University of Basel, Basel, Switzerland., Juge S; University Children's Hospital & Department of Biomedicine, University of Basel, Basel, Switzerland., Pereira AL; Department of Medical Oncology and Haematology, University Hospital Zürich, Zürich, Switzerland., Seguin J; University Children's Hospital & Department of Biomedicine, University of Basel, Basel, Switzerland.; Swiss Institute of Bioinformatics (SIB), Basel, Switzerland., El Taher A; Swiss Institute of Bioinformatics (SIB), Basel, Switzerland.; Bioinformatics Core Facility, University of Basel, Basel, Switzerland., Valigi F; University Children's Hospital & Department of Biomedicine, University of Basel, Basel, Switzerland., Jevtic Z; University Children's Hospital & Department of Biomedicine, University of Basel, Basel, Switzerland., Sivalingam R; University Children's Hospital & Department of Biomedicine, University of Basel, Basel, Switzerland., Bagger FO; University Children's Hospital & Department of Biomedicine, University of Basel, Basel, Switzerland.; Center for Genomic Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Büschl P; Department of Medical Oncology and Haematology, University Hospital Zürich, Zürich, Switzerland., Almosailleakh M; University Children's Hospital & Department of Biomedicine, University of Basel, Basel, Switzerland.; Biotech Research and Innovation Center (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Tzankov A; Institute for Pathology, University of Basel, Basel, Switzerland., Tong W; Division of Haematology, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Kurokawa M; Department of Haematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan., Nombela Arrieta C; Department of Medical Oncology and Haematology, University Hospital Zürich, Zürich, Switzerland., Schwaller J; University Children's Hospital & Department of Biomedicine, University of Basel, Basel, Switzerland. J.Schwaller@unibas.ch.
Source: Nature communications [Nat Commun] 2025 Dec 19; Vol. 17 (1), pp. 892. Date of Electronic Publication: 2025 Dec 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-025-67611-w