Recombination junctions from antibody isotype switching classify immune and DNA repair dysfunction.
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| Title: | Recombination junctions from antibody isotype switching classify immune and DNA repair dysfunction. |
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| Authors: | Vázquez García C; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Obermayer B; Core Unit Bioinformatics, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany., Keller B; Department of Rheumatology and Clinical Immunology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Lebedin M; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Ratswohl C; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany., Abolhassani H; Division of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.; Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children´s Medical Center, Tehran University of Medical Sciences, Tehran, Iran., Busse A; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; German Cancer Consortium (DKTK), partner site Berlin, a partnership between German Cancer Research Center (DKFZ) and Charité - Universitätsmedizin Berlin, Berlin, Germany., Di Virgilio M; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Mathas S; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Experimental and Clinical Research Center (ECRC), a junction cooperation between Charité and MDC, Berlin, Germany., Speiser D; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Department of Gynecology with Breast Center, Hereditary Breast and Ovarian Cancer Center, Charité - Universitätsmedizin Berlin, Berlin, Germany., Beule D; Core Unit Bioinformatics, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany., Pan-Hammarström Q; Division of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Warnatz K; Department of Rheumatology and Clinical Immunology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., de la Rosa K; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany. Kathrin.delaRosa@helmholtz-hzi.de.; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany. Kathrin.delaRosa@helmholtz-hzi.de.; Centre for Individualised Infection Medicine (CiiM), Hannover Medical School (MHH), Hannover, Germany. Kathrin.delaRosa@helmholtz-hzi.de.; Department of Personalized Immunotherapy, Centre for Individualized Infection Medicine (CiiM), Helmholtz Centre for Infection Research (HZI), Hannover, Germany. Kathrin.delaRosa@helmholtz-hzi.de. |
| Source: | Nature communications [Nat Commun] 2025 Dec 19; Vol. 16 (1), pp. 11331. Date of Electronic Publication: 2025 Dec 19. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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