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Mutant CHCHD10 disrupts cytochrome c oxidation and activates mitochondrial retrograde signaling.

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Title: Mutant CHCHD10 disrupts cytochrome c oxidation and activates mitochondrial retrograde signaling.
Authors: Campos-Ribeiro MA; Institut Pasteur, CNRS UMR 3691, Mitochondrial Biology Unit, Université Paris Cité, Paris, 25-28 Rue du Docteur Roux, 75015, France., Donnarumma E; Institut Pasteur, CNRS UMR 3691, Mitochondrial Biology Unit, Université Paris Cité, Paris, 25-28 Rue du Docteur Roux, 75015, France., Nolte H; Max-Planck-Institute for Biology of Ageing, Department of Mitochondrial Proteostasis, Joseph-Stelzmann-Str. 9b, Cologne, 50931, Germany., Cobine P; Department of Biological Sciences, Auburn University, Auburn, AL, USA., Vimont E; Institut Pasteur, CNRS UMR 3691, Mitochondrial Biology Unit, Université Paris Cité, Paris, 25-28 Rue du Docteur Roux, 75015, France., Milenkovic D; Max-Planck-Institute for Biology of Ageing, Department of Mitochondrial Proteostasis, Joseph-Stelzmann-Str. 9b, Cologne, 50931, Germany., Hernandez-Camacho JD; Institut Pasteur, CNRS UMR 3691, Mitochondrial Biology Unit, Université Paris Cité, Paris, 25-28 Rue du Docteur Roux, 75015, France., Langa-Vives F; Institut Pasteur, Mouse Genetics Engineering Center, Université Paris Cité, Paris, 25-28 Rue du Docteur Roux, 75015, France., Kornobis E; Institut Pasteur, Biomics core facility, Bioinformatics and Biostatistics Hub, Université Paris Cité, Paris, 25-28 Rue du Docteur Roux, 75015, France., Pénard E; Institut Pasteur, Ultrastructural Bioimaging Core Facility, Université Paris Cité, Paris, 25-28 Rue du Docteur Roux, 75015, France., Yde S; Institut Pasteur, CNRS UMR 3691, Mitochondrial Biology Unit, Université Paris Cité, Paris, 25-28 Rue du Docteur Roux, 75015, France., Langer T; Max-Planck-Institute for Biology of Ageing, Department of Mitochondrial Proteostasis, Joseph-Stelzmann-Str. 9b, Cologne, 50931, Germany., Paquis-Flucklinger V; Université Côte d'Azur (UniCA), Inserm U1081, CNRS UMR7284, Institute for Research and Aging (IRCAN), Mitochondria, Disease and Aging Team, Nice, France.; Department of Medical Genetics, Reference Centre for Mitochondrial Diseases, Centre Hospitalier Universitaire (CHU) de Nice, Nice, France., Wai T; Institut Pasteur, CNRS UMR 3691, Mitochondrial Biology Unit, Université Paris Cité, Paris, 25-28 Rue du Docteur Roux, 75015, France. timothy.wai@pasteur.fr.
Source: EMBO molecular medicine [EMBO Mol Med] 2026 Feb; Vol. 18 (2), pp. 542-574. Date of Electronic Publication: 2025 Dec 19.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1757-4684
DOI:10.1038/s44321-025-00358-5