HHLA3 transcriptionally promotes GPX2 to enhance anti-oxidative capacity by attenuating KEAP1-mediated NRF2 ubiquitination in lung adenocarcinoma.

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Title: HHLA3 transcriptionally promotes GPX2 to enhance anti-oxidative capacity by attenuating KEAP1-mediated NRF2 ubiquitination in lung adenocarcinoma.
Authors: Zhang C; Department of Occupational Health and Occupational Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China., Liang X; Department of Toxicology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China., Wang M; Department of Toxicology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China., Wang K; Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, 510515, China., Liu J; Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, 510515, China., Li C; Department of Toxicology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China., Kuang Y; Department of Toxicology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China., Liu J; Department of Toxicology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China., Zou F; Department of Occupational Health and Occupational Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China. Electronic address: zfei@smu.edu.cn., Zhou L; Department of Toxicology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China; Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, 510515, China; School of Forensic Medicine, Southern Medical University, Guangzhou, 510515, China; Department of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China. Electronic address: zhzliang@smu.edu.cn.
Source: Free radical biology & medicine [Free Radic Biol Med] 2026 Feb 16; Vol. 244, pp. 482-495. Date of Electronic Publication: 2025 Dec 19.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1873-4596
DOI:10.1016/j.freeradbiomed.2025.12.030