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HHLA3 transcriptionally promotes GPX2 to enhance anti-oxidative capacity by attenuating KEAP1-mediated NRF2 ubiquitination in lung adenocarcinoma.

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Title: HHLA3 transcriptionally promotes GPX2 to enhance anti-oxidative capacity by attenuating KEAP1-mediated NRF2 ubiquitination in lung adenocarcinoma.
Authors: Zhang C; Department of Occupational Health and Occupational Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China., Liang X; Department of Toxicology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China., Wang M; Department of Toxicology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China., Wang K; Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, 510515, China., Liu J; Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, 510515, China., Li C; Department of Toxicology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China., Kuang Y; Department of Toxicology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China., Liu J; Department of Toxicology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China., Zou F; Department of Occupational Health and Occupational Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China. Electronic address: zfei@smu.edu.cn., Zhou L; Department of Toxicology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China; Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, 510515, China; School of Forensic Medicine, Southern Medical University, Guangzhou, 510515, China; Department of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China. Electronic address: zhzliang@smu.edu.cn.
Source: Free radical biology & medicine [Free Radic Biol Med] 2026 Feb 16; Vol. 244, pp. 482-495. Date of Electronic Publication: 2025 Dec 19.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: HHLA3 transcriptionally promotes GPX2 to enhance anti-oxidative capacity by attenuating KEAP1-mediated NRF2 ubiquitination in lung adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+C%22">Zhang C</searchLink>; Department of Occupational Health and Occupational Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Liang+X%22">Liang X</searchLink>; Department of Toxicology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Wang+M%22">Wang M</searchLink>; Department of Toxicology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Wang+K%22">Wang K</searchLink>; Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; Department of Toxicology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Kuang+Y%22">Kuang Y</searchLink>; Department of Toxicology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Department of Toxicology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Zou+F%22">Zou F</searchLink>; Department of Occupational Health and Occupational Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China. Electronic address: zfei@smu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhou+L%22">Zhou L</searchLink>; Department of Toxicology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China; Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, 510515, China; School of Forensic Medicine, Southern Medical University, Guangzhou, 510515, China; Department of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China. Electronic address: zhzliang@smu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%228709159%22">Free radical biology & medicine</searchLink> [Free Radic Biol Med] 2026 Feb 16; Vol. 244, pp. 482-495. <i>Date of Electronic Publication: </i>2025 Dec 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8709159 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-4596 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2208915849%22">08915849 </searchLink><i>NLM ISO Abbreviation: </i>Free Radic Biol Med <i>Subsets: </i>MEDLINE
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              Text: 2026 Feb 16
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