Functional in vitro assessment of the HER2 Ile655Val variant on trastuzumab-induced cardiotoxicity in human cardiomyocytes.

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Title: Functional in vitro assessment of the HER2 Ile655Val variant on trastuzumab-induced cardiotoxicity in human cardiomyocytes.
Authors: Pozo-Agundo A; GENYO: Center for Genomics and Oncological Research: Pfizer-University of Granada-Junta de Andalucía, Granada, Spain. Electronic address: b22poaga@correo.ugr.es., García-Rodríguez S; GENYO: Center for Genomics and Oncological Research: Pfizer-University of Granada-Junta de Andalucía, Granada, Spain. Electronic address: garciarodriguez.sonia@gmail.com., Antúnez-Rodríguez A; GENYO: Center for Genomics and Oncological Research: Pfizer-University of Granada-Junta de Andalucía, Granada, Spain. Electronic address: albantunez@gmail.com., Chica-Redecillas L; Department of Biochemistry and Molecular Biology III and Immunology, Faculty of Medicine, University of Granada, Granada, Spain. Electronic address: luciachica@ugr.es., Cejas RB; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Center for Pharmacogenomics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address: rominabcejas@gmail.com., Lyra-Leite D; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Center for Pharmacogenomics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address: davi@clevercarnivore.com., Porras-Quesada P; GENYO: Center for Genomics and Oncological Research: Pfizer-University of Granada-Junta de Andalucía, Granada, Spain; Department of Biochemistry and Molecular Biology III and Immunology, Faculty of Medicine, University of Granada, Granada, Spain. Electronic address: pmporras@ugr.es., Gómez-Sánchez J; General Surgery and Digestive System Service, Hospital Universitario San Cecilio, Granada, Spain. Electronic address: javiergomezsanchez.jg@gmail.com., Mirón-Pozo B; General Surgery and Digestive System Service, Hospital Universitario San Cecilio, Granada, Spain. Electronic address: benimp75@hotmail.com., Álvarez-Cubero MJ; GENYO: Center for Genomics and Oncological Research: Pfizer-University of Granada-Junta de Andalucía, Granada, Spain; Department of Biochemistry and Molecular Biology III and Immunology, Faculty of Medicine, University of Granada, Granada, Spain; IBS, Biosanitary Research Institute (ibs. GRANADA), University of Granada, Granada, Spain. Electronic address: mjesusac@ugr.es., Burridge PW; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Center for Pharmacogenomics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address: paul.burridge@northwestern.edu., Martin F; GENYO: Center for Genomics and Oncological Research: Pfizer-University of Granada-Junta de Andalucía, Granada, Spain; Department of Biochemistry and Molecular Biology III and Immunology, Faculty of Medicine, University of Granada, Granada, Spain; IBS, Biosanitary Research Institute (ibs. GRANADA), University of Granada, Granada, Spain. Electronic address: francisco.martin@genyo.es., Martínez-González LJ; GENYO: Center for Genomics and Oncological Research: Pfizer-University of Granada-Junta de Andalucía, Granada, Spain; Department of Biochemistry and Molecular Biology III and Immunology, Faculty of Medicine, University of Granada, Granada, Spain; IBS, Biosanitary Research Institute (ibs. GRANADA), University of Granada, Granada, Spain. Electronic address: luisjavier.martinez@genyo.es., Dávila-Fajardo CL; GENYO: Center for Genomics and Oncological Research: Pfizer-University of Granada-Junta de Andalucía, Granada, Spain; Pharmacy Department, Hospital Universitario Virgen de las Nieves - Instituto de Investigación Biosanitaria (ibs.Granada), Granada, Spain. Electronic address: cristinal.davila.sspa@juntadeandalucia.es.
Source: European journal of pharmacology [Eur J Pharmacol] 2026 Jan 20; Vol. 1012, pp. 178484. Date of Electronic Publication: 2025 Dec 19.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1879-0712
DOI:10.1016/j.ejphar.2025.178484