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Functional in vitro assessment of the HER2 Ile655Val variant on trastuzumab-induced cardiotoxicity in human cardiomyocytes.

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Title: Functional in vitro assessment of the HER2 Ile655Val variant on trastuzumab-induced cardiotoxicity in human cardiomyocytes.
Authors: Pozo-Agundo A; GENYO: Center for Genomics and Oncological Research: Pfizer-University of Granada-Junta de Andalucía, Granada, Spain. Electronic address: b22poaga@correo.ugr.es., García-Rodríguez S; GENYO: Center for Genomics and Oncological Research: Pfizer-University of Granada-Junta de Andalucía, Granada, Spain. Electronic address: garciarodriguez.sonia@gmail.com., Antúnez-Rodríguez A; GENYO: Center for Genomics and Oncological Research: Pfizer-University of Granada-Junta de Andalucía, Granada, Spain. Electronic address: albantunez@gmail.com., Chica-Redecillas L; Department of Biochemistry and Molecular Biology III and Immunology, Faculty of Medicine, University of Granada, Granada, Spain. Electronic address: luciachica@ugr.es., Cejas RB; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Center for Pharmacogenomics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address: rominabcejas@gmail.com., Lyra-Leite D; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Center for Pharmacogenomics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address: davi@clevercarnivore.com., Porras-Quesada P; GENYO: Center for Genomics and Oncological Research: Pfizer-University of Granada-Junta de Andalucía, Granada, Spain; Department of Biochemistry and Molecular Biology III and Immunology, Faculty of Medicine, University of Granada, Granada, Spain. Electronic address: pmporras@ugr.es., Gómez-Sánchez J; General Surgery and Digestive System Service, Hospital Universitario San Cecilio, Granada, Spain. Electronic address: javiergomezsanchez.jg@gmail.com., Mirón-Pozo B; General Surgery and Digestive System Service, Hospital Universitario San Cecilio, Granada, Spain. Electronic address: benimp75@hotmail.com., Álvarez-Cubero MJ; GENYO: Center for Genomics and Oncological Research: Pfizer-University of Granada-Junta de Andalucía, Granada, Spain; Department of Biochemistry and Molecular Biology III and Immunology, Faculty of Medicine, University of Granada, Granada, Spain; IBS, Biosanitary Research Institute (ibs. GRANADA), University of Granada, Granada, Spain. Electronic address: mjesusac@ugr.es., Burridge PW; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Center for Pharmacogenomics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address: paul.burridge@northwestern.edu., Martin F; GENYO: Center for Genomics and Oncological Research: Pfizer-University of Granada-Junta de Andalucía, Granada, Spain; Department of Biochemistry and Molecular Biology III and Immunology, Faculty of Medicine, University of Granada, Granada, Spain; IBS, Biosanitary Research Institute (ibs. GRANADA), University of Granada, Granada, Spain. Electronic address: francisco.martin@genyo.es., Martínez-González LJ; GENYO: Center for Genomics and Oncological Research: Pfizer-University of Granada-Junta de Andalucía, Granada, Spain; Department of Biochemistry and Molecular Biology III and Immunology, Faculty of Medicine, University of Granada, Granada, Spain; IBS, Biosanitary Research Institute (ibs. GRANADA), University of Granada, Granada, Spain. Electronic address: luisjavier.martinez@genyo.es., Dávila-Fajardo CL; GENYO: Center for Genomics and Oncological Research: Pfizer-University of Granada-Junta de Andalucía, Granada, Spain; Pharmacy Department, Hospital Universitario Virgen de las Nieves - Instituto de Investigación Biosanitaria (ibs.Granada), Granada, Spain. Electronic address: cristinal.davila.sspa@juntadeandalucia.es.
Source: European journal of pharmacology [Eur J Pharmacol] 2026 Jan 20; Vol. 1012, pp. 178484. Date of Electronic Publication: 2025 Dec 19.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE
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  Data: Functional in vitro assessment of the HER2 Ile655Val variant on trastuzumab-induced cardiotoxicity in human cardiomyocytes.
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  Data: <searchLink fieldCode="AU" term="%22Pozo-Agundo+A%22">Pozo-Agundo A</searchLink>; GENYO: Center for Genomics and Oncological Research: Pfizer-University of Granada-Junta de Andalucía, Granada, Spain. Electronic address: b22poaga@correo.ugr.es.<br /><searchLink fieldCode="AU" term="%22García-Rodríguez+S%22">García-Rodríguez S</searchLink>; GENYO: Center for Genomics and Oncological Research: Pfizer-University of Granada-Junta de Andalucía, Granada, Spain. Electronic address: garciarodriguez.sonia@gmail.com.<br /><searchLink fieldCode="AU" term="%22Antúnez-Rodríguez+A%22">Antúnez-Rodríguez A</searchLink>; GENYO: Center for Genomics and Oncological Research: Pfizer-University of Granada-Junta de Andalucía, Granada, Spain. Electronic address: albantunez@gmail.com.<br /><searchLink fieldCode="AU" term="%22Chica-Redecillas+L%22">Chica-Redecillas L</searchLink>; Department of Biochemistry and Molecular Biology III and Immunology, Faculty of Medicine, University of Granada, Granada, Spain. Electronic address: luciachica@ugr.es.<br /><searchLink fieldCode="AU" term="%22Cejas+RB%22">Cejas RB</searchLink>; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Center for Pharmacogenomics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address: rominabcejas@gmail.com.<br /><searchLink fieldCode="AU" term="%22Lyra-Leite+D%22">Lyra-Leite D</searchLink>; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Center for Pharmacogenomics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address: davi@clevercarnivore.com.<br /><searchLink fieldCode="AU" term="%22Porras-Quesada+P%22">Porras-Quesada P</searchLink>; GENYO: Center for Genomics and Oncological Research: Pfizer-University of Granada-Junta de Andalucía, Granada, Spain; Department of Biochemistry and Molecular Biology III and Immunology, Faculty of Medicine, University of Granada, Granada, Spain. Electronic address: pmporras@ugr.es.<br /><searchLink fieldCode="AU" term="%22Gómez-Sánchez+J%22">Gómez-Sánchez J</searchLink>; General Surgery and Digestive System Service, Hospital Universitario San Cecilio, Granada, Spain. Electronic address: javiergomezsanchez.jg@gmail.com.<br /><searchLink fieldCode="AU" term="%22Mirón-Pozo+B%22">Mirón-Pozo B</searchLink>; General Surgery and Digestive System Service, Hospital Universitario San Cecilio, Granada, Spain. Electronic address: benimp75@hotmail.com.<br /><searchLink fieldCode="AU" term="%22Álvarez-Cubero+MJ%22">Álvarez-Cubero MJ</searchLink>; GENYO: Center for Genomics and Oncological Research: Pfizer-University of Granada-Junta de Andalucía, Granada, Spain; Department of Biochemistry and Molecular Biology III and Immunology, Faculty of Medicine, University of Granada, Granada, Spain; IBS, Biosanitary Research Institute (ibs. GRANADA), University of Granada, Granada, Spain. Electronic address: mjesusac@ugr.es.<br /><searchLink fieldCode="AU" term="%22Burridge+PW%22">Burridge PW</searchLink>; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Center for Pharmacogenomics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address: paul.burridge@northwestern.edu.<br /><searchLink fieldCode="AU" term="%22Martin+F%22">Martin F</searchLink>; GENYO: Center for Genomics and Oncological Research: Pfizer-University of Granada-Junta de Andalucía, Granada, Spain; Department of Biochemistry and Molecular Biology III and Immunology, Faculty of Medicine, University of Granada, Granada, Spain; IBS, Biosanitary Research Institute (ibs. GRANADA), University of Granada, Granada, Spain. Electronic address: francisco.martin@genyo.es.<br /><searchLink fieldCode="AU" term="%22Martínez-González+LJ%22">Martínez-González LJ</searchLink>; GENYO: Center for Genomics and Oncological Research: Pfizer-University of Granada-Junta de Andalucía, Granada, Spain; Department of Biochemistry and Molecular Biology III and Immunology, Faculty of Medicine, University of Granada, Granada, Spain; IBS, Biosanitary Research Institute (ibs. GRANADA), University of Granada, Granada, Spain. Electronic address: luisjavier.martinez@genyo.es.<br /><searchLink fieldCode="AU" term="%22Dávila-Fajardo+CL%22">Dávila-Fajardo CL</searchLink>; GENYO: Center for Genomics and Oncological Research: Pfizer-University of Granada-Junta de Andalucía, Granada, Spain; Pharmacy Department, Hospital Universitario Virgen de las Nieves - Instituto de Investigación Biosanitaria (ibs.Granada), Granada, Spain. Electronic address: cristinal.davila.sspa@juntadeandalucia.es.
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