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Discovery of novel progesterone-heterocyclic conjugates and their encapsulated polymeric nanoparticles as potential CDK8 inhibitors: lung cytotoxicity evaluation, gene expression, and molecular docking.

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Title: Discovery of novel progesterone-heterocyclic conjugates and their encapsulated polymeric nanoparticles as potential CDK8 inhibitors: lung cytotoxicity evaluation, gene expression, and molecular docking.
Authors: Omar YY; Postgraduate program in Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University Cairo Egypt.; Hormones Department, Medical Research and Clinical Studies Institute, National Research Centre Cairo Egypt gh.hamdi@nrc.sci.eg ghadanrc@yahoo.com., Elmasry GF; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University Cairo Egypt ghada.elmasry@pharma.cu.edu.eg., El-Kady DS; Hormones Department, Medical Research and Clinical Studies Institute, National Research Centre Cairo Egypt gh.hamdi@nrc.sci.eg ghadanrc@yahoo.com., Abd-Rabou AA; Hormones Department, Medical Research and Clinical Studies Institute, National Research Centre Cairo Egypt gh.hamdi@nrc.sci.eg ghadanrc@yahoo.com., El-Moghazy SM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University Cairo Egypt ghada.elmasry@pharma.cu.edu.eg., Awadallah FM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University Cairo Egypt ghada.elmasry@pharma.cu.edu.eg., Elmegeed GA; Hormones Department, Medical Research and Clinical Studies Institute, National Research Centre Cairo Egypt gh.hamdi@nrc.sci.eg ghadanrc@yahoo.com., Elsayed GH; Hormones Department, Medical Research and Clinical Studies Institute, National Research Centre Cairo Egypt gh.hamdi@nrc.sci.eg ghadanrc@yahoo.com.; Stem Cell Lab, Centre of Excellence for Advanced Sciences, National Research Centre Cairo Egypt.
Source: RSC medicinal chemistry [RSC Med Chem] 2025 Dec 18. Date of Electronic Publication: 2025 Dec 18.
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101759460 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2632-8682 (Electronic) Linking ISSN: 26328682 NLM ISO Abbreviation: RSC Med Chem
Database: MEDLINE Ultimate
Description
ISSN:2632-8682
DOI:10.1039/d5md00794a