A Common Ancestry-Specific Sodium Channel Variant Increases Susceptibility to Drug-Induced QTc Prolongation: Evidence From a Large Biobank.

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Title: A Common Ancestry-Specific Sodium Channel Variant Increases Susceptibility to Drug-Induced QTc Prolongation: Evidence From a Large Biobank.
Authors: Stewart R; School of Medicine (R.S.), Vanderbilt University Medical Center, Nashville, TN., Lowery BD; Department of Medicine, Division of Cardiovascular Medicine (B.D.L., E.F.-E., Y.W., Q.S.W., G.D.), Vanderbilt University Medical Center, Nashville, TN., Farber-Eger E; Department of Medicine, Division of Cardiovascular Medicine (B.D.L., E.F.-E., Y.W., Q.S.W., G.D.), Vanderbilt University Medical Center, Nashville, TN., Wada Y; Department of Medicine, Division of Cardiovascular Medicine (B.D.L., E.F.-E., Y.W., Q.S.W., G.D.), Vanderbilt University Medical Center, Nashville, TN., Roden DM; Department of Biomedical Informatics (D.M.R., Q.S.W.), Vanderbilt University Medical Center, Nashville, TN., Wells QS; Department of Medicine, Division of Cardiovascular Medicine (B.D.L., E.F.-E., Y.W., Q.S.W., G.D.), Vanderbilt University Medical Center, Nashville, TN.; Department of Biomedical Informatics (D.M.R., Q.S.W.), Vanderbilt University Medical Center, Nashville, TN., Davogustto G; Department of Medicine, Division of Cardiovascular Medicine (B.D.L., E.F.-E., Y.W., Q.S.W., G.D.), Vanderbilt University Medical Center, Nashville, TN.
Source: Circulation [Circulation] 2025 Dec 23; Vol. 152 (25), pp. 1806-1808. Date of Electronic Publication: 2025 Dec 22.
Publication Type: Letter
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0147763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4539 (Electronic) Linking ISSN: 00097322 NLM ISO Abbreviation: Circulation Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
Description
ISSN:1524-4539
DOI:10.1161/CIRCULATIONAHA.125.074358