A Common Ancestry-Specific Sodium Channel Variant Increases Susceptibility to Drug-Induced QTc Prolongation: Evidence From a Large Biobank.
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| Title: | A Common Ancestry-Specific Sodium Channel Variant Increases Susceptibility to Drug-Induced QTc Prolongation: Evidence From a Large Biobank. |
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| Authors: | Stewart R; School of Medicine (R.S.), Vanderbilt University Medical Center, Nashville, TN., Lowery BD; Department of Medicine, Division of Cardiovascular Medicine (B.D.L., E.F.-E., Y.W., Q.S.W., G.D.), Vanderbilt University Medical Center, Nashville, TN., Farber-Eger E; Department of Medicine, Division of Cardiovascular Medicine (B.D.L., E.F.-E., Y.W., Q.S.W., G.D.), Vanderbilt University Medical Center, Nashville, TN., Wada Y; Department of Medicine, Division of Cardiovascular Medicine (B.D.L., E.F.-E., Y.W., Q.S.W., G.D.), Vanderbilt University Medical Center, Nashville, TN., Roden DM; Department of Biomedical Informatics (D.M.R., Q.S.W.), Vanderbilt University Medical Center, Nashville, TN., Wells QS; Department of Medicine, Division of Cardiovascular Medicine (B.D.L., E.F.-E., Y.W., Q.S.W., G.D.), Vanderbilt University Medical Center, Nashville, TN.; Department of Biomedical Informatics (D.M.R., Q.S.W.), Vanderbilt University Medical Center, Nashville, TN., Davogustto G; Department of Medicine, Division of Cardiovascular Medicine (B.D.L., E.F.-E., Y.W., Q.S.W., G.D.), Vanderbilt University Medical Center, Nashville, TN. |
| Source: | Circulation [Circulation] 2025 Dec 23; Vol. 152 (25), pp. 1806-1808. Date of Electronic Publication: 2025 Dec 22. |
| Publication Type: | Letter |
| Journal Info: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0147763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4539 (Electronic) Linking ISSN: 00097322 NLM ISO Abbreviation: Circulation Subsets: MEDLINE; In Process |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41428794 AccessLevel: 2 PubType: Editorial & Opinion PubTypeId: editorialOpinion PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A Common Ancestry-Specific Sodium Channel Variant Increases Susceptibility to Drug-Induced QTc Prolongation: Evidence From a Large Biobank. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Stewart+R%22">Stewart R</searchLink>; School of Medicine (R.S.), Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Lowery+BD%22">Lowery BD</searchLink>; Department of Medicine, Division of Cardiovascular Medicine (B.D.L., E.F.-E., Y.W., Q.S.W., G.D.), Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Farber-Eger+E%22">Farber-Eger E</searchLink>; Department of Medicine, Division of Cardiovascular Medicine (B.D.L., E.F.-E., Y.W., Q.S.W., G.D.), Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Wada+Y%22">Wada Y</searchLink>; Department of Medicine, Division of Cardiovascular Medicine (B.D.L., E.F.-E., Y.W., Q.S.W., G.D.), Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Roden+DM%22">Roden DM</searchLink>; Department of Biomedical Informatics (D.M.R., Q.S.W.), Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Wells+QS%22">Wells QS</searchLink>; Department of Medicine, Division of Cardiovascular Medicine (B.D.L., E.F.-E., Y.W., Q.S.W., G.D.), Vanderbilt University Medical Center, Nashville, TN.; Department of Biomedical Informatics (D.M.R., Q.S.W.), Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Davogustto+G%22">Davogustto G</searchLink>; Department of Medicine, Division of Cardiovascular Medicine (B.D.L., E.F.-E., Y.W., Q.S.W., G.D.), Vanderbilt University Medical Center, Nashville, TN. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220147763%22">Circulation</searchLink> [Circulation] 2025 Dec 23; Vol. 152 (25), pp. 1806-1808. <i>Date of Electronic Publication: </i>2025 Dec 22. – Name: TypePub Label: Publication Type Group: TypPub Data: Letter – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Lippincott+Williams+%26+Wilkins%22">Lippincott Williams & Wilkins </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0147763 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1524-4539 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200097322%22">00097322 </searchLink><i>NLM ISO Abbreviation: </i>Circulation <i>Subsets: </i>MEDLINE; In Process |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41428794 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1161/CIRCULATIONAHA.125.074358 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1806 Titles: – TitleFull: A Common Ancestry-Specific Sodium Channel Variant Increases Susceptibility to Drug-Induced QTc Prolongation: Evidence From a Large Biobank. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Stewart R – PersonEntity: Name: NameFull: Lowery BD – PersonEntity: Name: NameFull: Farber-Eger E – PersonEntity: Name: NameFull: Wada Y – PersonEntity: Name: NameFull: Roden DM – PersonEntity: Name: NameFull: Wells QS – PersonEntity: Name: NameFull: Davogustto G IsPartOfRelationships: – BibEntity: Dates: – D: 23 M: 12 Text: 2025 Dec 23 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1524-4539 Numbering: – Type: volume Value: 152 – Type: issue Value: 25 Titles: – TitleFull: Circulation Type: main |
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