Small-molecule inhibitor of C‑terminal HSP90 dimerization modulates autophagy and functions synergistically with mTOR inhibition to kill cisplatin-resistant cancer cells.
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| Title: | Small-molecule inhibitor of C‑terminal HSP90 dimerization modulates autophagy and functions synergistically with mTOR inhibition to kill cisplatin-resistant cancer cells. |
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| Authors: | David C; Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany., Sun Y; Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany.; Department of Urology, Weifang People's Hospital, Shandong Second Medical University, Weifang, China., Woloschin V; Heinrich Heine University Düsseldorf, Faculty of Mathematics and Natural Sciences, Institute for Pharmaceutical and Medicinal Chemistry, Düsseldorf, Germany., Vogt M; Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany., Dienstbier N; Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany., Friedrich A; Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany., Krings KS; Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany., Schlütermann D; Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany., Berning L; Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany., Lungerich B; Heinrich Heine University Düsseldorf, Faculty of Mathematics and Natural Sciences, Institute for Pharmaceutical and Medicinal Chemistry, Düsseldorf, Germany., Akgün S; Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany., Mendiburo MJ; Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany., Gertzen CGW; Heinrich Heine University Düsseldorf, Faculty of Mathematics and Natural Sciences, Institute for Pharmaceutical and Medicinal Chemistry, Düsseldorf, Germany.; Heinrich Heine University Düsseldorf, Center for Structural Studies (CSS), Düsseldorf, Germany., Borkhardt A; Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany., Wesselborg S; Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany., Gohlke H; Heinrich Heine University Düsseldorf, Faculty of Mathematics and Natural Sciences, Institute for Pharmaceutical and Medicinal Chemistry, Düsseldorf, Germany.; Institute of Bio- and Geosciences (IBG-4: Bioinformatics), Forschungszentrum Jülich GmbH, Jülich, Germany., Bhatia S; Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany. sanil.bhatia@med.uni-duesseldorf.de., Kurz T; Heinrich Heine University Düsseldorf, Faculty of Mathematics and Natural Sciences, Institute for Pharmaceutical and Medicinal Chemistry, Düsseldorf, Germany. thomas.kurz@hhu.de., Stork B; Institute of Molecular Medicine I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany. bjoern.stork@hhu.de. |
| Source: | Cell death & disease [Cell Death Dis] 2025 Dec 23; Vol. 17 (1), pp. 130. Date of Electronic Publication: 2025 Dec 23. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-4889 |
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| DOI: | 10.1038/s41419-025-08330-4 |
