Glutamate indicators with increased sensitivity and tailored deactivation rates.

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Title: Glutamate indicators with increased sensitivity and tailored deactivation rates.
Authors: Aggarwal A; Allen Institute for Neural Dynamics, Seattle, WA, USA.; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.; University of Calgary Cumming School of Medicine and Hotchkiss Brain Institute, Calgary, Alberta, Canada., Negrean A; Allen Institute for Neural Dynamics, Seattle, WA, USA., Chen Y; Institute of Neuroscience and Munich Cluster for Systems Neurology, Technical University of Munich, Munich, Germany., Iyer R; Department of Physics, University of California, San Diego, La Jolla, CA, USA., Reep D; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.; The GENIE Project Team, Janelia Research Campus, Ashburn, VA, USA., Liu A; University College London, London, UK., Palutla A; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA., Xie ME; Allen Institute for Neural Dynamics, Seattle, WA, USA.; Johns Hopkins University, Baltimore, MD, USA., MacLennan BJ; Allen Institute for Neural Dynamics, Seattle, WA, USA., Hagihara KM; Allen Institute for Neural Dynamics, Seattle, WA, USA., Kinsey LW; Allen Institute for Neural Dynamics, Seattle, WA, USA.; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA., Sun JL; Neuronal Cell Biology Division, Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA., Yao P; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA., Zheng J; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.; The GENIE Project Team, Janelia Research Campus, Ashburn, VA, USA., Tsang A; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.; The GENIE Project Team, Janelia Research Campus, Ashburn, VA, USA., Tsegaye G; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.; The GENIE Project Team, Janelia Research Campus, Ashburn, VA, USA., Zhang Y; Institute of Neuroscience and Munich Cluster for Systems Neurology, Technical University of Munich, Munich, Germany., Patel RH; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA., Arthur BJ; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA., Hiblot J; Max Planck Institute for Medical Research, Heidelberg, Germany., Leippe P; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Wien, Austria., Tarnawski M; Max Planck Institute for Medical Research, Heidelberg, Germany., Marvin JS; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA., Vevea JD; Neuronal Cell Biology Division, Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA., Turaga SC; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA., Tebo AG; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA., Carandini M; University College London, London, UK., Rossi LF; University College London, London, UK.; Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia, Rovereto, Italy., Kleinfeld D; Department of Physics, University of California, San Diego, La Jolla, CA, USA.; Department of Neurobiology, University of California, San Diego, La Jolla, CA, USA., Konnerth A; Institute of Neuroscience and Munich Cluster for Systems Neurology, Technical University of Munich, Munich, Germany., Svoboda K; Allen Institute for Neural Dynamics, Seattle, WA, USA.; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA., Turner GC; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.; The GENIE Project Team, Janelia Research Campus, Ashburn, VA, USA., Hasseman JP; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA. hassemanj@janelia.hhmi.org.; The GENIE Project Team, Janelia Research Campus, Ashburn, VA, USA. hassemanj@janelia.hhmi.org., Podgorski K; Allen Institute for Neural Dynamics, Seattle, WA, USA. kaspar.podgorski@alleninstitute.org.; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA. kaspar.podgorski@alleninstitute.org.
Source: Nature methods [Nat Methods] 2026 Feb; Vol. 23 (2), pp. 417-425. Date of Electronic Publication: 2025 Dec 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101215604 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1548-7105 (Electronic) Linking ISSN: 15487091 NLM ISO Abbreviation: Nat Methods Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1548-7105
DOI:10.1038/s41592-025-02965-z