Design and synthesis of sorafenib-inspired benzofuran hybrids as VEGFR-2 inhibitors: antiproliferative evaluation, mechanistic insights, and docking studies in hepatocellular carcinoma.
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| Title: | Design and synthesis of sorafenib-inspired benzofuran hybrids as VEGFR-2 inhibitors: antiproliferative evaluation, mechanistic insights, and docking studies in hepatocellular carcinoma. |
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| Authors: | Shehda MS; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Horus University-Egypt New Damietta 34518 Egypt mshehda@horus.edu.eg., Almatary AM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Horus University-Egypt New Damietta 34518 Egypt mshehda@horus.edu.eg., Salem MSH; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Suez Canal University Ismailia 41522 Egypt.; SANKEN, The University of Osaka Mihogaoka Ibaraki Osaka 567-0047 Japan mohamedsalem43@sanken.osaka-u.ac.jp., Aboutaleb MH; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Horus University-Egypt New Damietta 34518 Egypt mshehda@horus.edu.eg., Takizawa S; SANKEN, The University of Osaka Mihogaoka Ibaraki Osaka 567-0047 Japan mohamedsalem43@sanken.osaka-u.ac.jp., Abdel Aziz YM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Suez Canal University Ismailia 41522 Egypt., El-Sayed MAA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Mansoura University Mansoura 35516 Egypt magdaaziz1@yahoo.com.; Department of pharmaceutic organic chemistry, Faculty of Pharmacy, Mansoura National University Gamasa 7731168 Egypt., Elrayess R; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Suez Canal University Ismailia 41522 Egypt.; Pharmaceutical Organic Chemistry Department, College of Pharmacy, Al-Ayen Iraqi University, AUIQ An Nasiriyah 6400 Iraq. |
| Source: | RSC medicinal chemistry [RSC Med Chem] 2025 Dec 12. Date of Electronic Publication: 2025 Dec 12. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101759460 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2632-8682 (Electronic) Linking ISSN: 26328682 NLM ISO Abbreviation: RSC Med Chem |
| Database: | MEDLINE Ultimate |
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