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Validation of a data-driven clustering model for MASLD: Evidence from three large-scale Asian cohorts.

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Title: Validation of a data-driven clustering model for MASLD: Evidence from three large-scale Asian cohorts.
Authors: Zhou XD; MAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China., Song SJ; Medical Data Analytics Centre, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; State Key Laboratory of Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China., Guo CY; Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Chen QF; Medical Care Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; Institute of Aging, Wenzhou Medical University, Wenzhou, China., Lai-Hung Wong G; Medical Data Analytics Centre, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; State Key Laboratory of Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China., Ye TR; MAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China., Bee Goh GB; Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore.; Duke-NUS Medical School, Singapore., Bee YM; Duke-NUS Medical School, Singapore.; Department of Endocrinology, Singapore General Hospital, Singapore., Lian LY; MAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China., Cheuk-Fung Yip T; Medical Data Analytics Centre, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; State Key Laboratory of Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China., Che-To Lai J; Medical Data Analytics Centre, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; State Key Laboratory of Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China., Lei SY; MAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China., Liu WY; Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China., Fan RC; Department of Cardiovascular Medicine, The Heart Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China., Hong CL; Department of Cardiovascular Medicine, The Heart Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China., Targher G; Department of Medicine, University of Verona, Verona, Italy.; Metabolic Diseases Research Unit, IRCCS Sacro Cuore-Don Calabria Hospital, Negrar di Valpolicella, Italy., Byrne CD; Southampton National Institute for Health and Care Research Biomedical Research Centre, University Hospital Southampton, and University of Southampton, Southampton General Hospital, Southampton, UK., Marot G; ULR 2694 METRICS / MODAL, University of Lille, CHU Lille, Inria, Lille, France., Raverdy V; Translational Research for Diabetes UMR 1190, University of Lille, Inserm, Institut Pasteur Lille, CHU Lille, Lille, France., Pattou F; Translational Research for Diabetes UMR 1190, University of Lille, Inserm, Institut Pasteur Lille, CHU Lille, Lille, France., Zheng Lim DY; Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore.; Duke-NUS Medical School, Singapore.; Data Science and Artificial Intelligence Lab, Singapore General Hospital, Singapore., Wai-Sun Wong V; Medical Data Analytics Centre, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; State Key Laboratory of Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China., Zheng MH; MAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China.
Source: JHEP reports : innovation in hepatology [JHEP Rep] 2025 Oct 17; Vol. 8 (1), pp. 101645. Date of Electronic Publication: 2025 Oct 17 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101761237 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-5559 (Electronic) Linking ISSN: 25895559 NLM ISO Abbreviation: JHEP Rep Subsets: In Process
Database: MEDLINE Ultimate
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  Data: Validation of a data-driven clustering model for MASLD: Evidence from three large-scale Asian cohorts.
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  Data: <searchLink fieldCode="AU" term="%22Zhou+XD%22">Zhou XD</searchLink>; MAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Song+SJ%22">Song SJ</searchLink>; Medical Data Analytics Centre, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; State Key Laboratory of Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Guo+CY%22">Guo CY</searchLink>; Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chen+QF%22">Chen QF</searchLink>; Medical Care Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; Institute of Aging, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Lai-Hung+Wong+G%22">Lai-Hung Wong G</searchLink>; Medical Data Analytics Centre, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; State Key Laboratory of Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Ye+TR%22">Ye TR</searchLink>; MAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Bee+Goh+GB%22">Bee Goh GB</searchLink>; Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore.; Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Bee+YM%22">Bee YM</searchLink>; Duke-NUS Medical School, Singapore.; Department of Endocrinology, Singapore General Hospital, Singapore.<br /><searchLink fieldCode="AU" term="%22Lian+LY%22">Lian LY</searchLink>; MAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Cheuk-Fung+Yip+T%22">Cheuk-Fung Yip T</searchLink>; Medical Data Analytics Centre, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; State Key Laboratory of Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Che-To+Lai+J%22">Che-To Lai J</searchLink>; Medical Data Analytics Centre, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; 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Department of Cardiovascular Medicine, The Heart Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Targher+G%22">Targher G</searchLink>; Department of Medicine, University of Verona, Verona, Italy.; Metabolic Diseases Research Unit, IRCCS Sacro Cuore-Don Calabria Hospital, Negrar di Valpolicella, Italy.<br /><searchLink fieldCode="AU" term="%22Byrne+CD%22">Byrne CD</searchLink>; Southampton National Institute for Health and Care Research Biomedical Research Centre, University Hospital Southampton, and University of Southampton, Southampton General Hospital, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Marot+G%22">Marot G</searchLink>; ULR 2694 METRICS / MODAL, University of Lille, CHU Lille, Inria, Lille, France.<br /><searchLink fieldCode="AU" term="%22Raverdy+V%22">Raverdy V</searchLink>; Translational Research for Diabetes UMR 1190, University of Lille, Inserm, Institut Pasteur Lille, CHU Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Pattou+F%22">Pattou F</searchLink>; Translational Research for Diabetes UMR 1190, University of Lille, Inserm, Institut Pasteur Lille, CHU Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Zheng+Lim+DY%22">Zheng Lim DY</searchLink>; Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore.; Duke-NUS Medical School, Singapore.; Data Science and Artificial Intelligence Lab, Singapore General Hospital, Singapore.<br /><searchLink fieldCode="AU" term="%22Wai-Sun+Wong+V%22">Wai-Sun Wong V</searchLink>; Medical Data Analytics Centre, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; State Key Laboratory of Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Zheng+MH%22">Zheng MH</searchLink>; MAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China.
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