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Generation and ophthalmological characterization of oculocutaneous albinism type 1 pig models by selection-free genome editing.

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Title: Generation and ophthalmological characterization of oculocutaneous albinism type 1 pig models by selection-free genome editing.
Authors: Oh D; Laboratory of Veterinary Embryology and Biotechnology (VETEMBIO), Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.; Institute of Stem Cell and Regenerative Medicine (ISCRM), Chungbuk NationalUniversity, Cheongju, Republic of Korea.; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Seok C; Department of Precision Medicine, Sungkyunkwan University School of Medicine, Suwon, 16419, Republic of Korea., Park HW; Naason Science, Inc., Cheongju, 28160, Republic of Korea., Park S; Department of Precision Medicine, Sungkyunkwan University School of Medicine, Suwon, 16419, Republic of Korea., Lee J; Laboratory of Veterinary Embryology and Biotechnology (VETEMBIO), Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.; Institute of Stem Cell and Regenerative Medicine (ISCRM), Chungbuk NationalUniversity, Cheongju, Republic of Korea.; Department of Companion Animal Industry, Semyung University, Jecheon, 27136, Republic of Korea., Choi H; Laboratory of Veterinary Embryology and Biotechnology (VETEMBIO), Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.; Institute of Stem Cell and Regenerative Medicine (ISCRM), Chungbuk NationalUniversity, Cheongju, Republic of Korea.; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Jawad A; Laboratory of Veterinary Embryology and Biotechnology (VETEMBIO), Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.; Institute of Stem Cell and Regenerative Medicine (ISCRM), Chungbuk NationalUniversity, Cheongju, Republic of Korea., Ham J; Laboratory of Veterinary Embryology and Biotechnology (VETEMBIO), Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.; Institute of Stem Cell and Regenerative Medicine (ISCRM), Chungbuk NationalUniversity, Cheongju, Republic of Korea., Jang H; Department of Veterinary Anatomy and Animal Behavior, College of VeterinaryMedicine and BK21 FOUR Program, Chonnam National University, Gwangju, Korea., Lee SC; Cronex Inc., Cheongju, 28174, Korea., Oh BC; Department of Plastic and Reconstructive Surgery, Johns Hopkins UniversitySchool of Medicine, Baltimore, MD, USA., Moon C; Department of Veterinary Anatomy and Animal Behavior, College of VeterinaryMedicine and BK21 FOUR Program, Chonnam National University, Gwangju, Korea., Park KH; Naason Science, Inc., Cheongju, 28160, Republic of Korea. kyungho@naasonscience.com., Hyun SH; Laboratory of Veterinary Embryology and Biotechnology (VETEMBIO), Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea. shhyun@cbu.ac.kr.; Institute of Stem Cell and Regenerative Medicine (ISCRM), Chungbuk NationalUniversity, Cheongju, Republic of Korea. shhyun@cbu.ac.kr.; Graduate School of Veterinary Biosecurity and Protection, Chungbuk NationalUniversity, Cheongju, Republic of Korea. shhyun@cbu.ac.kr., Kim D; Department of Precision Medicine, Sungkyunkwan University School of Medicine, Suwon, 16419, Republic of Korea. dskim89@skku.edu.
Source: Scientific reports [Sci Rep] 2025 Dec 24; Vol. 15 (1), pp. 44564. Date of Electronic Publication: 2025 Dec 24.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
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  Data: Generation and ophthalmological characterization of oculocutaneous albinism type 1 pig models by selection-free genome editing.
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  Data: <searchLink fieldCode="AU" term="%22Oh+D%22">Oh D</searchLink>; Laboratory of Veterinary Embryology and Biotechnology (VETEMBIO), Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.; Institute of Stem Cell and Regenerative Medicine (ISCRM), Chungbuk NationalUniversity, Cheongju, Republic of Korea.; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.<br /><searchLink fieldCode="AU" term="%22Seok+C%22">Seok C</searchLink>; Department of Precision Medicine, Sungkyunkwan University School of Medicine, Suwon, 16419, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+HW%22">Park HW</searchLink>; Naason Science, Inc., Cheongju, 28160, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+S%22">Park S</searchLink>; Department of Precision Medicine, Sungkyunkwan University School of Medicine, Suwon, 16419, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+J%22">Lee J</searchLink>; Laboratory of Veterinary Embryology and Biotechnology (VETEMBIO), Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.; Institute of Stem Cell and Regenerative Medicine (ISCRM), Chungbuk NationalUniversity, Cheongju, Republic of Korea.; Department of Companion Animal Industry, Semyung University, Jecheon, 27136, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Choi+H%22">Choi H</searchLink>; Laboratory of Veterinary Embryology and Biotechnology (VETEMBIO), Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.; Institute of Stem Cell and Regenerative Medicine (ISCRM), Chungbuk NationalUniversity, Cheongju, Republic of Korea.; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.<br /><searchLink fieldCode="AU" term="%22Jawad+A%22">Jawad A</searchLink>; Laboratory of Veterinary Embryology and Biotechnology (VETEMBIO), Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.; Institute of Stem Cell and Regenerative Medicine (ISCRM), Chungbuk NationalUniversity, Cheongju, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Ham+J%22">Ham J</searchLink>; Laboratory of Veterinary Embryology and Biotechnology (VETEMBIO), Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.; Institute of Stem Cell and Regenerative Medicine (ISCRM), Chungbuk NationalUniversity, Cheongju, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jang+H%22">Jang H</searchLink>; Department of Veterinary Anatomy and Animal Behavior, College of VeterinaryMedicine and BK21 FOUR Program, Chonnam National University, Gwangju, Korea.<br /><searchLink fieldCode="AU" term="%22Lee+SC%22">Lee SC</searchLink>; Cronex Inc., Cheongju, 28174, Korea.<br /><searchLink fieldCode="AU" term="%22Oh+BC%22">Oh BC</searchLink>; Department of Plastic and Reconstructive Surgery, Johns Hopkins UniversitySchool of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Moon+C%22">Moon C</searchLink>; Department of Veterinary Anatomy and Animal Behavior, College of VeterinaryMedicine and BK21 FOUR Program, Chonnam National University, Gwangju, Korea.<br /><searchLink fieldCode="AU" term="%22Park+KH%22">Park KH</searchLink>; Naason Science, Inc., Cheongju, 28160, Republic of Korea. kyungho@naasonscience.com.<br /><searchLink fieldCode="AU" term="%22Hyun+SH%22">Hyun SH</searchLink>; Laboratory of Veterinary Embryology and Biotechnology (VETEMBIO), Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea. shhyun@cbu.ac.kr.; Institute of Stem Cell and Regenerative Medicine (ISCRM), Chungbuk NationalUniversity, Cheongju, Republic of Korea. shhyun@cbu.ac.kr.; Graduate School of Veterinary Biosecurity and Protection, Chungbuk NationalUniversity, Cheongju, Republic of Korea. shhyun@cbu.ac.kr.<br /><searchLink fieldCode="AU" term="%22Kim+D%22">Kim D</searchLink>; Department of Precision Medicine, Sungkyunkwan University School of Medicine, Suwon, 16419, Republic of Korea. dskim89@skku.edu.
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