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The role of MICOS in modulating mitochondrial dynamics and structural changes in vulnerable regions of Alzheimer's Disease.

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Title: The role of MICOS in modulating mitochondrial dynamics and structural changes in vulnerable regions of Alzheimer's Disease.
Authors: Shao B; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Kula B; Del Monte Institute for Neuroscience, Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA., Le H; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.; Department of Integrative Genomics and Epidemiology, Meharry Medical College, Nashville, TN, USA.; Department of Biomedical Sciences, School of Graduate Studies, Meharry Medical College, Nashville, TN, USA., Venkhatesh P; Department of Biology, Indian Institute of Science Education and Research (IISER) Tirupati, AP, 517619, India.; The Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, TN, USA.; Department of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, TN, USA.; Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, TN, USA., Katti P; Department of Biology, Indian Institute of Science Education and Research (IISER) Tirupati, AP, 517619, India.; The Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, TN, USA.; Department of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, TN, USA.; Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, TN, USA., Marshall AG; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.; The Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, TN, USA.; Department of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, TN, USA.; Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, TN, USA.; Department of Biomedical Sciences, School of Graduate Studies, Meharry Medical College, Nashville, TN, USA., Chittaranjan S; Del Monte Institute for Neuroscience, Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA., Thapilyal S; Department of Biology, Indian Institute of Science Education and Research (IISER) Tirupati, AP, 517619, India.; The Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, TN, USA.; Department of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, TN, USA.; Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, TN, USA., Namdar HK; Department of Biology, Indian Institute of Science Education and Research (IISER) Tirupati, AP, 517619, India.; The Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, TN, USA.; Department of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, TN, USA.; Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, TN, USA., Nivedya C; Department of Biology, Indian Institute of Science Education and Research (IISER) Tirupati, AP, 517619, India.; The Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, TN, USA.; Department of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, TN, USA.; Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, TN, USA., Roszczyk A; Del Monte Institute for Neuroscience, Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA., Mobley H; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Killion M; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., St John E; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Martin P; Department of Biomedical Sciences, School of Graduate Studies, Meharry Medical College, Nashville, TN, USA., Rodrigiuez B; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.; Department of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, TN, USA.; Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, TN, USA.; Department of Integrative Genomics and Epidemiology, Meharry Medical College, Nashville, TN, USA., Hamilton M; Department of Biomedical Sciences, School of Graduate Studies, Meharry Medical College, Nashville, TN, USA., Bell L; Department of Biomedical Sciences, School of Graduate Studies, Meharry Medical College, Nashville, TN, USA., Wyckoff SM; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Moran LA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Philips M; Department of Integrative Biology, Oregon State University, Corvallis, OR, USA., Hubert D; Department of Integrative Biology, Oregon State University, Corvallis, OR, USA., Tomeau B; Department of Integrative Genomics and Epidemiology, Meharry Medical College, Nashville, TN, USA., Afolabi JM; Department of Medicine, Division of Genetic Medicine and Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA., Kirabo A; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.; Department of Medicine, Division of Genetic Medicine and Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Institute for Infection, Immunology and Inflammation (VI4), Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Institute for Global Health, Vanderbilt University Medical Center, Nashville, TN, USA., Blanco I; Department of Medicine, Division of Genetic Medicine and Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA., Reasonover S; Department of Medicine, Division of Genetic Medicine and Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA., Drake LE; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Lippmann ES; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Evans C; Department of Cell Biology, Duke University School of Medicine, Durham, NC, USA.; Howard Hughes Medical Institute, Duke University School of Medicine, Durham, NC, USA., Santisteban MM; Department of Medicine, Division of Genetic Medicine and Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA., Cheairs TG; Department of Biomedical Sciences, School of Graduate Studies, Meharry Medical College, Nashville, TN, USA., Mesenga S; Departments of Physiological Sciences, Pathology and Microbiology, HAND Research Group, School of Medicine and Health Sciences, Livingstone, Zambia.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Institute for Global Health, Vanderbilt University Medical Center, Nashville, TN, USA., Wanjalla C; Department of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, USA., Gaddy J; Department of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, USA., McMillan R; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.; Department of Medicine, Division of Genetic Medicine and Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, USA., Hernandez Perez CP; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Paing HH; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Schafer JC; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA., Mobley B; Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA., Berry J; Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA., Crabtree A; Department of Physics and Astronomy, Vanderbilt University, Nashville, TN, USA.; Frist Center for Autism & Innovation, Vanderbilt University, Nashville, TN, USA.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Kovtun O; Department of Chemistry, Vanderbilt University, Nashville, TN, USA., Goodwin S; Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, TN, USA., Garza Lopez E; Department of Internal Medicine, University of Iowa, Iowa City, IA, USA.; The Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, TN, USA.; Department of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, TN, USA.; Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, TN, USA.; Del Monte Institute for Neuroscience, Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.; Department of Biology, Indian Institute of Science Education and Research (IISER) Tirupati, AP, 517619, India., Dash C; The Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, TN, USA.; Department of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, TN, USA.; Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, TN, USA., Dai DF; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Miller-Fleming TW; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Hinton A Jr; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.; Frist Center for Autism & Innovation, Vanderbilt University, Nashville, TN, USA.; Department of Medicine, Division of Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA.; The Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, TN, USA.; Department of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, TN, USA.; Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, TN, USA.; Department of Biomedical Sciences, School of Graduate Studies, Meharry Medical College, Nashville, TN, USA., Smith NA; Del Monte Institute for Neuroscience, Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Dec 16. Date of Electronic Publication: 2025 Dec 16.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: The role of MICOS in modulating mitochondrial dynamics and structural changes in vulnerable regions of Alzheimer's Disease.
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Department of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, TN, USA.; Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Katti+P%22">Katti P</searchLink>; Department of Biology, Indian Institute of Science Education and Research (IISER) Tirupati, AP, 517619, India.; The Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, TN, USA.; Department of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, TN, USA.; Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Marshall+AG%22">Marshall AG</searchLink>; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.; The Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, TN, USA.; Department of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, TN, USA.; 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Department of Biology, Indian Institute of Science Education and Research (IISER) Tirupati, AP, 517619, India.; The Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, TN, USA.; Department of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, TN, USA.; Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Nivedya+C%22">Nivedya C</searchLink>; Department of Biology, Indian Institute of Science Education and Research (IISER) Tirupati, AP, 517619, India.; The Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, TN, USA.; Department of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, TN, USA.; Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Roszczyk+A%22">Roszczyk A</searchLink>; 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Department of Integrative Biology, Oregon State University, Corvallis, OR, USA.<br /><searchLink fieldCode="AU" term="%22Hubert+D%22">Hubert D</searchLink>; Department of Integrative Biology, Oregon State University, Corvallis, OR, USA.<br /><searchLink fieldCode="AU" term="%22Tomeau+B%22">Tomeau B</searchLink>; Department of Integrative Genomics and Epidemiology, Meharry Medical College, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Afolabi+JM%22">Afolabi JM</searchLink>; Department of Medicine, Division of Genetic Medicine and Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Kirabo+A%22">Kirabo A</searchLink>; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.; Department of Medicine, Division of Genetic Medicine and Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA.; 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Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Garza+Lopez+E%22">Garza Lopez E</searchLink>; Department of Internal Medicine, University of Iowa, Iowa City, IA, USA.; The Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, TN, USA.; Department of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, TN, USA.; Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, TN, USA.; Del Monte Institute for Neuroscience, Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.; Department of Biology, Indian Institute of Science Education and Research (IISER) Tirupati, AP, 517619, India.<br /><searchLink fieldCode="AU" term="%22Dash+C%22">Dash C</searchLink>; The Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, TN, USA.; 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Department of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, TN, USA.; Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, TN, USA.; Department of Biomedical Sciences, School of Graduate Studies, Meharry Medical College, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Smith+NA%22">Smith NA</searchLink>; Del Monte Institute for Neuroscience, Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
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            NameFull: Reasonover S
      – PersonEntity:
          Name:
            NameFull: Drake LE
      – PersonEntity:
          Name:
            NameFull: Lippmann ES
      – PersonEntity:
          Name:
            NameFull: Evans C
      – PersonEntity:
          Name:
            NameFull: Santisteban MM
      – PersonEntity:
          Name:
            NameFull: Cheairs TG
      – PersonEntity:
          Name:
            NameFull: Mesenga S
      – PersonEntity:
          Name:
            NameFull: Wanjalla C
      – PersonEntity:
          Name:
            NameFull: Gaddy J
      – PersonEntity:
          Name:
            NameFull: McMillan R
      – PersonEntity:
          Name:
            NameFull: Hernandez Perez CP
      – PersonEntity:
          Name:
            NameFull: Paing HH
      – PersonEntity:
          Name:
            NameFull: Schafer JC
      – PersonEntity:
          Name:
            NameFull: Mobley B
      – PersonEntity:
          Name:
            NameFull: Berry J
      – PersonEntity:
          Name:
            NameFull: Crabtree A
      – PersonEntity:
          Name:
            NameFull: Kovtun O
      – PersonEntity:
          Name:
            NameFull: Goodwin S
      – PersonEntity:
          Name:
            NameFull: Garza Lopez E
      – PersonEntity:
          Name:
            NameFull: Dash C
      – PersonEntity:
          Name:
            NameFull: Dai DF
      – PersonEntity:
          Name:
            NameFull: Miller-Fleming TW
      – PersonEntity:
          Name:
            NameFull: Hinton A Jr
      – PersonEntity:
          Name:
            NameFull: Smith NA
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 16
              M: 12
              Text: 2025 Dec 16
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 2692-8205
          Titles:
            – TitleFull: BioRxiv : the preprint server for biology
              Type: main
ResultId 1