Philadelphia chromosome-positive acute lymphoblastic leukaemia in children and adolescents: A changing treatment landscape and a methodological challenge.

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Title: Philadelphia chromosome-positive acute lymphoblastic leukaemia in children and adolescents: A changing treatment landscape and a methodological challenge.
Authors: Balduzzi A; Department of Pediatrics, Pediatric Hematology-Oncology Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy., Valsecchi MG; School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.; Biostatistics and Clinical Epidemiology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Tran TH; Division of Pediatric Hematology-Oncology, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine, Montréal, Quebec, Canada.; Department of Pediatrics, Faculty of Medicine, University of Montréal, Montréal, Quebec, Canada., Zuna J; CLIP (Childhood Leukaemia Investigation Prague), Prague, Czech Republic.; Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.; University Hospital Motol, Prague, Czech Republic., Leoni V; Department of Pediatrics, Pediatric Hematology-Oncology Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Cario G; Department of Pediatrics I, Pediatric Hematology and Oncology, ALL-BFM Study Group, University Medical Center Schleswig-Holstein, Kiel, Germany., Fazio G; School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Gandemer V; Department of Pediatric Hematology and Oncology, CHU Hôpital Sud, Rennes, France., Tasian SK; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Pediatrics and Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., van der Sluis IM; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Peccatori N; Department of Pediatrics, Pediatric Hematology-Oncology Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy., Parasole R; Department of Oncology, Hematology and Cellular Therapy, Santobono-Pausilipon Children's Hospital, Naples, Italy., Monterisi S; Clinical Trials and Phase I Unit, Pediatric Hematology-Oncology Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Loh ML; Seattle Children's Hospital, Seattle, Washington, USA.; Ben Towne Center for Childhood Cancer and Blood Disorders Research and Department of Pediatrics, Fred Hutchinson Cancer Center, University of Washington, Seattle, Washington, USA., Devidas M; Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Hunger SP; Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Kairalla JA; Department of Biostatistics, Colleges of Medicine and Public Health & Health Professions, University of Florida, Gainesville, Florida, USA., De Lorenzo P; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Silverman LB; Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Columbia University Irving Medical Center, New York, New York, USA., Biondi A; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Source: British journal of haematology [Br J Haematol] 2026 Mar; Vol. 208 (3), pp. 1127-1132. Date of Electronic Publication: 2025 Dec 25.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE; In Process
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  Data: Philadelphia chromosome-positive acute lymphoblastic leukaemia in children and adolescents: A changing treatment landscape and a methodological challenge.
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  Data: <searchLink fieldCode="AU" term="%22Balduzzi+A%22">Balduzzi A</searchLink>; Department of Pediatrics, Pediatric Hematology-Oncology Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Valsecchi+MG%22">Valsecchi MG</searchLink>; School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.; Biostatistics and Clinical Epidemiology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Tran+TH%22">Tran TH</searchLink>; Division of Pediatric Hematology-Oncology, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine, Montréal, Quebec, Canada.; Department of Pediatrics, Faculty of Medicine, University of Montréal, Montréal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Zuna+J%22">Zuna J</searchLink>; CLIP (Childhood Leukaemia Investigation Prague), Prague, Czech Republic.; Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.; University Hospital Motol, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Leoni+V%22">Leoni V</searchLink>; Department of Pediatrics, Pediatric Hematology-Oncology Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Cario+G%22">Cario G</searchLink>; Department of Pediatrics I, Pediatric Hematology and Oncology, ALL-BFM Study Group, University Medical Center Schleswig-Holstein, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Fazio+G%22">Fazio G</searchLink>; School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Gandemer+V%22">Gandemer V</searchLink>; Department of Pediatric Hematology and Oncology, CHU Hôpital Sud, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Tasian+SK%22">Tasian SK</searchLink>; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Pediatrics and Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Sluis+IM%22">van der Sluis IM</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Peccatori+N%22">Peccatori N</searchLink>; Department of Pediatrics, Pediatric Hematology-Oncology Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Parasole+R%22">Parasole R</searchLink>; Department of Oncology, Hematology and Cellular Therapy, Santobono-Pausilipon Children's Hospital, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Monterisi+S%22">Monterisi S</searchLink>; Clinical Trials and Phase I Unit, Pediatric Hematology-Oncology Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Loh+ML%22">Loh ML</searchLink>; Seattle Children's Hospital, Seattle, Washington, USA.; Ben Towne Center for Childhood Cancer and Blood Disorders Research and Department of Pediatrics, Fred Hutchinson Cancer Center, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Devidas+M%22">Devidas M</searchLink>; Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Hunger+SP%22">Hunger SP</searchLink>; Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Kairalla+JA%22">Kairalla JA</searchLink>; Department of Biostatistics, Colleges of Medicine and Public Health & Health Professions, University of Florida, Gainesville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22De+Lorenzo+P%22">De Lorenzo P</searchLink>; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Silverman+LB%22">Silverman LB</searchLink>; Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Columbia University Irving Medical Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Biondi+A%22">Biondi A</searchLink>; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
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  Data: <searchLink fieldCode="JN" term="%220372544%22">British journal of haematology</searchLink> [Br J Haematol] 2026 Mar; Vol. 208 (3), pp. 1127-1132. <i>Date of Electronic Publication: </i>2025 Dec 25.
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              Text: 2026 Mar
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