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PAK1 inhibitor NVS-PAK1-1 preserves dendritic spines in amyloid/tau exposed neurons and 5xFAD mice.

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Title: PAK1 inhibitor NVS-PAK1-1 preserves dendritic spines in amyloid/tau exposed neurons and 5xFAD mice.
Authors: Yang T; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Huhe H; Department of Medicine-Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Williams SP; Department of Medicine-Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Kaur S; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Ay YA; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Davis-Gilbert ZW; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Cary GA; The Jackson Laboratory, Bar Harbor, Maine, USA.; The Emory-Sage-SGC-Jax TREAT-AD Center, Emory, USA., Paisie C; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA., Butler RR 3rd; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Wiley J; Sage Bionetworks, Seattle, Washington, USA., Betarbet R; The Emory-Sage-SGC-Jax TREAT-AD Center, Emory, USA.; Department of Neurology, Emory University, Atlanta, Georgia, USA., Fu H; The Emory-Sage-SGC-Jax TREAT-AD Center, Emory, USA.; Department of Pharmacology and Chemical Biology, Emory University, Atlanta, Georgia, USA., Duong D; Emory Integrated Proteomics Core (EIPC), Emory University, Atlanta, Georgia, USA., Seyfried NT; Emory Integrated Proteomics Core (EIPC), Emory University, Atlanta, Georgia, USA.; Department of Department of Biochemistry, Emory University, Atlanta, Georgia, USA., Leal K; The Emory-Sage-SGC-Jax TREAT-AD Center, Emory, USA.; Sage Bionetworks, Seattle, Washington, USA., Carter GW; The Jackson Laboratory, Bar Harbor, Maine, USA.; The Emory-Sage-SGC-Jax TREAT-AD Center, Emory, USA.; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA., Edwards A; The Emory-Sage-SGC-Jax TREAT-AD Center, Emory, USA.; Department of Medical Genetics and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Levey AI; The Emory-Sage-SGC-Jax TREAT-AD Center, Emory, USA.; Department of Neurology, Emory University, Atlanta, Georgia, USA., Capener JL; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Drewry DH; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Hossain MA; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Oh HJ; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Axtman AD; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; The Emory-Sage-SGC-Jax TREAT-AD Center, Emory, USA., Sukoff Rizzo SJ; Department of Medicine-Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; The Emory-Sage-SGC-Jax TREAT-AD Center, Emory, USA.; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Longo FM; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.; The Emory-Sage-SGC-Jax TREAT-AD Center, Emory, USA.; Wu Tsai Neuroscience Institute, Stanford University, Stanford, California, USA.
Corporate Authors: Emory‐Sage‐SGC‐Jax TREAT‐AD Center; The Emory-Sage-SGC-Jax TREAT-AD Center, Emory, USA.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Dec; Vol. 21 (12), pp. e71033.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: PAK1 inhibitor NVS-PAK1-1 preserves dendritic spines in amyloid/tau exposed neurons and 5xFAD mice.
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  Data: <searchLink fieldCode="AU" term="%22Yang+T%22">Yang T</searchLink>; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Huhe+H%22">Huhe H</searchLink>; Department of Medicine-Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Williams+SP%22">Williams SP</searchLink>; Department of Medicine-Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Kaur+S%22">Kaur S</searchLink>; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Ay+YA%22">Ay YA</searchLink>; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Davis-Gilbert+ZW%22">Davis-Gilbert ZW</searchLink>; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Cary+GA%22">Cary GA</searchLink>; The Jackson Laboratory, Bar Harbor, Maine, USA.; The Emory-Sage-SGC-Jax TREAT-AD Center, Emory, USA.<br /><searchLink fieldCode="AU" term="%22Paisie+C%22">Paisie C</searchLink>; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Butler+RR+3rd%22">Butler RR 3rd</searchLink>; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Wiley+J%22">Wiley J</searchLink>; Sage Bionetworks, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Betarbet+R%22">Betarbet R</searchLink>; The Emory-Sage-SGC-Jax TREAT-AD Center, Emory, USA.; Department of Neurology, Emory University, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Fu+H%22">Fu H</searchLink>; The Emory-Sage-SGC-Jax TREAT-AD Center, Emory, USA.; Department of Pharmacology and Chemical Biology, Emory University, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Duong+D%22">Duong D</searchLink>; Emory Integrated Proteomics Core (EIPC), Emory University, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Seyfried+NT%22">Seyfried NT</searchLink>; Emory Integrated Proteomics Core (EIPC), Emory University, Atlanta, Georgia, USA.; Department of Department of Biochemistry, Emory University, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Leal+K%22">Leal K</searchLink>; The Emory-Sage-SGC-Jax TREAT-AD Center, Emory, USA.; Sage Bionetworks, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Carter+GW%22">Carter GW</searchLink>; The Jackson Laboratory, Bar Harbor, Maine, USA.; The Emory-Sage-SGC-Jax TREAT-AD Center, Emory, USA.; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Edwards+A%22">Edwards A</searchLink>; The Emory-Sage-SGC-Jax TREAT-AD Center, Emory, USA.; Department of Medical Genetics and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Levey+AI%22">Levey AI</searchLink>; The Emory-Sage-SGC-Jax TREAT-AD Center, Emory, USA.; Department of Neurology, Emory University, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Capener+JL%22">Capener JL</searchLink>; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Drewry+DH%22">Drewry DH</searchLink>; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Hossain+MA%22">Hossain MA</searchLink>; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Oh+HJ%22">Oh HJ</searchLink>; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Axtman+AD%22">Axtman AD</searchLink>; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; The Emory-Sage-SGC-Jax TREAT-AD Center, Emory, USA.<br /><searchLink fieldCode="AU" term="%22Sukoff+Rizzo+SJ%22">Sukoff Rizzo SJ</searchLink>; Department of Medicine-Aging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; The Emory-Sage-SGC-Jax TREAT-AD Center, Emory, USA.; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Longo+FM%22">Longo FM</searchLink>; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.; The Emory-Sage-SGC-Jax TREAT-AD Center, Emory, USA.; Wu Tsai Neuroscience Institute, Stanford University, Stanford, California, USA.
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  Data: <searchLink fieldCode="JN" term="%22101231978%22">Alzheimer's & dementia : the journal of the Alzheimer's Association</searchLink> [Alzheimers Dement] 2025 Dec; Vol. 21 (12), pp. e71033.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22John+Wiley+%26+Sons%2C+Ltd%22">John Wiley & Sons, Ltd </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101231978 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1552-5279 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215525260%22">15525260 </searchLink><i>NLM ISO Abbreviation: </i>Alzheimers Dement <i>Subsets: </i>MEDLINE
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