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First-in-human clinical trial of high-dose sodium copper chlorophyllin: Pharmacology and efficacy as a dual immunomodulatory/antiviral agent.

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Title: First-in-human clinical trial of high-dose sodium copper chlorophyllin: Pharmacology and efficacy as a dual immunomodulatory/antiviral agent.
Authors: Patwardhan RS; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India; Radiobiology & Omics Lab, Radiological Research Unit, Bhabha Atomic Research Centre Facility, Kharghar, Navi Mumbai 410210, India., Rizvi ZA; Translational Health Science and Technology Institute (THSTI), Faridabad 121001, India., Gota V; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India; Advanced Centre for Treatment, Research & Education in Cancer (ACTREC-TMC), Kharghar 410210, India. Electronic address: vgota@actrec.gov.in., Checker R; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India., Singh B; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India., Maurya DK; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India., Pal D; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India., Ramani N; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India., Kumar BK; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India., Purohit V; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India., Mathapati BS; ICMR-National Institute of Virology (ICMR-NIV), Pune 411001, India., Mullick J; ICMR-National Institute of Virology (ICMR-NIV), Pune 411001, India., Ghanty TK; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India., Gupta S; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India; Advanced Centre for Treatment, Research & Education in Cancer (ACTREC-TMC), Kharghar 410210, India., Joshi M; Innovative Drug Research Solution Labs Pvt, Ltd. Bengaluru 560099, India., Madki S; Innovative Drug Research Solution Labs Pvt, Ltd. Bengaluru 560099, India., Awasthi A; Translational Health Science and Technology Institute (THSTI), Faridabad 121001, India. Electronic address: aawasthi@thsti.res.in., Sandur SK; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India. Electronic address: sskumar@barc.gov.in., Sharma D; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India; Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai 400094, India. Electronic address: dsharma@barc.gov.in.
Source: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2026 Jan; Vol. 150, pp. 157689. Date of Electronic Publication: 2025 Dec 12.
Publication Type: Journal Article; Clinical Trial, Phase I
Journal Info: Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1618-095X
DOI:10.1016/j.phymed.2025.157689