Integrated stress response inhibition prolongs the lifespan of a Pelizaeus-Merzbacher disease mouse model by increasing oligodendrocyte survival.

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Title: Integrated stress response inhibition prolongs the lifespan of a Pelizaeus-Merzbacher disease mouse model by increasing oligodendrocyte survival.
Authors: Chen Y; Department of Biology, Loyola University Chicago, Chicago, IL, USA. ychen55@luc.edu., Kunjamma RB; Department of Neurology, Division of Multiple Sclerosis and Neuroimmunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Calico Life Sciences LLC, South San Francisco, CA, USA., Lin K; Calico Life Sciences LLC, South San Francisco, CA, USA., Kai L; Department of Neurology, Division of Multiple Sclerosis and Neuroimmunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Dima M; Department of Neurology, Division of Multiple Sclerosis and Neuroimmunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Bruce K; Department of Biology, Loyola University Chicago, Chicago, IL, USA., Steckler I; Department of Biology, Loyola University Chicago, Chicago, IL, USA., Che YH; Department of Neurology, Division of Multiple Sclerosis and Neuroimmunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Chan-Zervas J; Department of Biology, Loyola University Chicago, Chicago, IL, USA., Eugenin von Bernhardi J; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA., Connelly C; Department of Integrative Biology, University of California Berkeley, Berkeley, CA, USA., Ece S; Department of Biology, Loyola University Chicago, Chicago, IL, USA., Newell G; Department of Biology, Loyola University Chicago, Chicago, IL, USA., Bergles DE; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA.; Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD, USA., Sidrauski C; Calico Life Sciences LLC, South San Francisco, CA, USA., Popko B; Department of Neurology, Division of Multiple Sclerosis and Neuroimmunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. brian.popko@northwestern.edu.
Source: Nature communications [Nat Commun] 2025 Dec 26; Vol. 17 (1), pp. 1285. Date of Electronic Publication: 2025 Dec 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-025-68045-0