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Integrated stress response inhibition prolongs the lifespan of a Pelizaeus-Merzbacher disease mouse model by increasing oligodendrocyte survival.

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Title: Integrated stress response inhibition prolongs the lifespan of a Pelizaeus-Merzbacher disease mouse model by increasing oligodendrocyte survival.
Authors: Chen Y; Department of Biology, Loyola University Chicago, Chicago, IL, USA. ychen55@luc.edu., Kunjamma RB; Department of Neurology, Division of Multiple Sclerosis and Neuroimmunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Calico Life Sciences LLC, South San Francisco, CA, USA., Lin K; Calico Life Sciences LLC, South San Francisco, CA, USA., Kai L; Department of Neurology, Division of Multiple Sclerosis and Neuroimmunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Dima M; Department of Neurology, Division of Multiple Sclerosis and Neuroimmunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Bruce K; Department of Biology, Loyola University Chicago, Chicago, IL, USA., Steckler I; Department of Biology, Loyola University Chicago, Chicago, IL, USA., Che YH; Department of Neurology, Division of Multiple Sclerosis and Neuroimmunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Chan-Zervas J; Department of Biology, Loyola University Chicago, Chicago, IL, USA., Eugenin von Bernhardi J; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA., Connelly C; Department of Integrative Biology, University of California Berkeley, Berkeley, CA, USA., Ece S; Department of Biology, Loyola University Chicago, Chicago, IL, USA., Newell G; Department of Biology, Loyola University Chicago, Chicago, IL, USA., Bergles DE; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA.; Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD, USA., Sidrauski C; Calico Life Sciences LLC, South San Francisco, CA, USA., Popko B; Department of Neurology, Division of Multiple Sclerosis and Neuroimmunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. brian.popko@northwestern.edu.
Source: Nature communications [Nat Commun] 2025 Dec 26; Vol. 17 (1), pp. 1285. Date of Electronic Publication: 2025 Dec 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Integrated stress response inhibition prolongs the lifespan of a Pelizaeus-Merzbacher disease mouse model by increasing oligodendrocyte survival.
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  Data: <searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of Biology, Loyola University Chicago, Chicago, IL, USA. ychen55@luc.edu.<br /><searchLink fieldCode="AU" term="%22Kunjamma+RB%22">Kunjamma RB</searchLink>; Department of Neurology, Division of Multiple Sclerosis and Neuroimmunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Calico Life Sciences LLC, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lin+K%22">Lin K</searchLink>; Calico Life Sciences LLC, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kai+L%22">Kai L</searchLink>; Department of Neurology, Division of Multiple Sclerosis and Neuroimmunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Dima+M%22">Dima M</searchLink>; Department of Neurology, Division of Multiple Sclerosis and Neuroimmunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Bruce+K%22">Bruce K</searchLink>; Department of Biology, Loyola University Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Steckler+I%22">Steckler I</searchLink>; Department of Biology, Loyola University Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Che+YH%22">Che YH</searchLink>; Department of Neurology, Division of Multiple Sclerosis and Neuroimmunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Chan-Zervas+J%22">Chan-Zervas J</searchLink>; Department of Biology, Loyola University Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Eugenin+von+Bernhardi+J%22">Eugenin von Bernhardi J</searchLink>; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Connelly+C%22">Connelly C</searchLink>; Department of Integrative Biology, University of California Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ece+S%22">Ece S</searchLink>; Department of Biology, Loyola University Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Newell+G%22">Newell G</searchLink>; Department of Biology, Loyola University Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Bergles+DE%22">Bergles DE</searchLink>; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA.; Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Sidrauski+C%22">Sidrauski C</searchLink>; Calico Life Sciences LLC, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Popko+B%22">Popko B</searchLink>; Department of Neurology, Division of Multiple Sclerosis and Neuroimmunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. brian.popko@northwestern.edu.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Dec 26; Vol. 17 (1), pp. 1285. <i>Date of Electronic Publication: </i>2025 Dec 26.
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