Phosphodiesterase ENPP2, which is co-upregulated in obese and pregnant mice, is essential for islet beta cell compensation during obesity.

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Title: Phosphodiesterase ENPP2, which is co-upregulated in obese and pregnant mice, is essential for islet beta cell compensation during obesity.
Authors: Zhou Y; State Key Laboratory of Ultrasound in Medicine and Engineering, Chongqing Medical University, Chongqing, China., Zeng Y; Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Chen Y; State Key Laboratory of Ultrasound in Medicine and Engineering, Chongqing Medical University, Chongqing, China., Zhang L; Medical Laboratory, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Zhen Q; Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Chen Y; Department of Hepatobiliary Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Cheng R; School of Basic Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Rui.cheng@cqmu.edu.cn., Wang Y; State Key Laboratory of Ultrasound in Medicine and Engineering, Chongqing Medical University, Chongqing, China. wangyancq@cqmu.edu.cn., Ge Q; Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. geqian@hospital.cqmu.edu.cn.
Source: Diabetologia [Diabetologia] 2026 Apr; Vol. 69 (4), pp. 1000-1020. Date of Electronic Publication: 2025 Dec 26.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0428 (Electronic) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-0428
DOI:10.1007/s00125-025-06639-5