View in EDS HTML Full Text PDF Full Text

Genetic evidence for PARP1 trapping as a driver of PARP inhibitor efficacy in BRCA mutant cancer cells.

Saved in:
Bibliographic Details
Title: Genetic evidence for PARP1 trapping as a driver of PARP inhibitor efficacy in BRCA mutant cancer cells.
Authors: Ribeiro J; OTD Bioscience, Early Oncology, AstraZeneca, CambridgeCB20AA, United Kingdom., Hansen K; Discovery Sciences, R&D, AstraZeneca, CambridgeCB20AA,United Kingdom., van Beek L; Discovery Sciences, R&D, AstraZeneca, CambridgeCB20AA,United Kingdom., Stubbs C; Discovery Sciences, R&D, AstraZeneca, CambridgeCB20AA,United Kingdom., Frigola J; Oncology Data Science, Oncology R&D, AstraZeneca, CambridgeCB20AA,United Kingdom., Talbot S; OTD Bioscience, Early Oncology, AstraZeneca, CambridgeCB20AA, United Kingdom., Bentouati S; OTD Bioscience, Early Oncology, AstraZeneca, CambridgeCB20AA, United Kingdom., Hall J; OTD Bioscience, Early Oncology, AstraZeneca, CambridgeCB20AA, United Kingdom., Wijnhoven PWG; OTD Bioscience, Early Oncology, AstraZeneca, CambridgeCB20AA, United Kingdom., Armenia J; Oncology Data Science, Oncology R&D, AstraZeneca, CambridgeCB20AA,United Kingdom., Schimpl M; Discovery Sciences, R&D, AstraZeneca, CambridgeCB20AA,United Kingdom., Forment JV; OTD Bioscience, Early Oncology, AstraZeneca, CambridgeCB20AA, United Kingdom., Albertella MR; OTD Bioscience, Early Oncology, AstraZeneca, CambridgeCB20AA, United Kingdom., O'Connor MJ; OTD Bioscience, Early Oncology, AstraZeneca, CambridgeCB20AA, United Kingdom., Illuzzi G; OTD Bioscience, Early Oncology, AstraZeneca, CambridgeCB20AA, United Kingdom.
Source: Nucleic acids research [Nucleic Acids Res] 2025 Nov 26; Vol. 53 (22).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41459749
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Genetic evidence for PARP1 trapping as a driver of PARP inhibitor efficacy in BRCA mutant cancer cells.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Ribeiro+J%22">Ribeiro J</searchLink>; OTD Bioscience, Early Oncology, AstraZeneca, CambridgeCB20AA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hansen+K%22">Hansen K</searchLink>; Discovery Sciences, R&D, AstraZeneca, CambridgeCB20AA,United Kingdom.<br /><searchLink fieldCode="AU" term="%22van+Beek+L%22">van Beek L</searchLink>; Discovery Sciences, R&D, AstraZeneca, CambridgeCB20AA,United Kingdom.<br /><searchLink fieldCode="AU" term="%22Stubbs+C%22">Stubbs C</searchLink>; Discovery Sciences, R&D, AstraZeneca, CambridgeCB20AA,United Kingdom.<br /><searchLink fieldCode="AU" term="%22Frigola+J%22">Frigola J</searchLink>; Oncology Data Science, Oncology R&D, AstraZeneca, CambridgeCB20AA,United Kingdom.<br /><searchLink fieldCode="AU" term="%22Talbot+S%22">Talbot S</searchLink>; OTD Bioscience, Early Oncology, AstraZeneca, CambridgeCB20AA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Bentouati+S%22">Bentouati S</searchLink>; OTD Bioscience, Early Oncology, AstraZeneca, CambridgeCB20AA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hall+J%22">Hall J</searchLink>; OTD Bioscience, Early Oncology, AstraZeneca, CambridgeCB20AA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Wijnhoven+PWG%22">Wijnhoven PWG</searchLink>; OTD Bioscience, Early Oncology, AstraZeneca, CambridgeCB20AA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Armenia+J%22">Armenia J</searchLink>; Oncology Data Science, Oncology R&D, AstraZeneca, CambridgeCB20AA,United Kingdom.<br /><searchLink fieldCode="AU" term="%22Schimpl+M%22">Schimpl M</searchLink>; Discovery Sciences, R&D, AstraZeneca, CambridgeCB20AA,United Kingdom.<br /><searchLink fieldCode="AU" term="%22Forment+JV%22">Forment JV</searchLink>; OTD Bioscience, Early Oncology, AstraZeneca, CambridgeCB20AA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Albertella+MR%22">Albertella MR</searchLink>; OTD Bioscience, Early Oncology, AstraZeneca, CambridgeCB20AA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22O'Connor+MJ%22">O'Connor MJ</searchLink>; OTD Bioscience, Early Oncology, AstraZeneca, CambridgeCB20AA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Illuzzi+G%22">Illuzzi G</searchLink>; OTD Bioscience, Early Oncology, AstraZeneca, CambridgeCB20AA, United Kingdom.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%220411011%22">Nucleic acids research</searchLink> [Nucleic Acids Res] 2025 Nov 26; Vol. 53 (22).
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0411011 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1362-4962 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203051048%22">03051048 </searchLink><i>NLM ISO Abbreviation: </i>Nucleic Acids Res <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41459749
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1093/nar/gkaf1398
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: Genetic evidence for PARP1 trapping as a driver of PARP inhibitor efficacy in BRCA mutant cancer cells.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Ribeiro J
      – PersonEntity:
          Name:
            NameFull: Hansen K
      – PersonEntity:
          Name:
            NameFull: van Beek L
      – PersonEntity:
          Name:
            NameFull: Stubbs C
      – PersonEntity:
          Name:
            NameFull: Frigola J
      – PersonEntity:
          Name:
            NameFull: Talbot S
      – PersonEntity:
          Name:
            NameFull: Bentouati S
      – PersonEntity:
          Name:
            NameFull: Hall J
      – PersonEntity:
          Name:
            NameFull: Wijnhoven PWG
      – PersonEntity:
          Name:
            NameFull: Armenia J
      – PersonEntity:
          Name:
            NameFull: Schimpl M
      – PersonEntity:
          Name:
            NameFull: Forment JV
      – PersonEntity:
          Name:
            NameFull: Albertella MR
      – PersonEntity:
          Name:
            NameFull: O'Connor MJ
      – PersonEntity:
          Name:
            NameFull: Illuzzi G
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 26
              M: 11
              Text: 2025 Nov 26
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1362-4962
          Numbering:
            – Type: volume
              Value: 53
            – Type: issue
              Value: 22
          Titles:
            – TitleFull: Nucleic acids research
              Type: main
ResultId 1