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Akkermansia muciniphila alleviates experimental colitis through FXR-mediated repression of unspliced XBP1.

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Title: Akkermansia muciniphila alleviates experimental colitis through FXR-mediated repression of unspliced XBP1.
Authors: Bu F; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Department of Colorectal Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital of Hangzhou Medical College, Hangzhou, China.; Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China., Zhang K; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; No.1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.; Department of Basic Pharmacology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China., Song B; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; No.1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.; Department of Basic Pharmacology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China., He L; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.; No.1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China., Lu Z; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.; No.1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China., Yuan X; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.; No.1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China., Chen C; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.; No.1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China., Jiang F; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.; No.1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China., Tao Y; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.; No.1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China., Zhang W; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.; No.1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China., Zhang D; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.; No.1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China., Chen Y; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.; No.1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China., Wang Q; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; No.1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.; Department of Basic Pharmacology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Source: MSystems [mSystems] 2026 Feb 17; Vol. 11 (2), pp. e0158925. Date of Electronic Publication: 2025 Dec 29.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101680636 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2379-5077 (Electronic) Linking ISSN: 23795077 NLM ISO Abbreviation: mSystems Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Akkermansia muciniphila alleviates experimental colitis through FXR-mediated repression of unspliced XBP1.
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  Data: <searchLink fieldCode="AU" term="%22Bu+F%22">Bu F</searchLink>; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Department of Colorectal Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital of Hangzhou Medical College, Hangzhou, China.; Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+K%22">Zhang K</searchLink>; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; No.1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.; Department of Basic Pharmacology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Song+B%22">Song B</searchLink>; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; No.1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.; Department of Basic Pharmacology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22He+L%22">He L</searchLink>; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.; No.1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Lu+Z%22">Lu Z</searchLink>; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.; No.1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Yuan+X%22">Yuan X</searchLink>; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.; No.1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Chen+C%22">Chen C</searchLink>; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.; No.1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Jiang+F%22">Jiang F</searchLink>; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.; No.1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Tao+Y%22">Tao Y</searchLink>; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.; No.1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zhang+W%22">Zhang W</searchLink>; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.; No.1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zhang+D%22">Zhang D</searchLink>; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.; No.1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.; No.1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.; No.1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.; Department of Basic Pharmacology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
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