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A mouse model of busulfan-induced ovarian toxicity and evidence for attenuation with mTOR inhibition.

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Title: A mouse model of busulfan-induced ovarian toxicity and evidence for attenuation with mTOR inhibition.
Authors: Deguchi M; Department of Obstetrics and Gynecology, Shiga University of Medical Science, 520-2192 Seta Tsukinowa-cho, Otsu, Shiga, Japan., Tanaka Y; Department of Obstetrics and Gynecology, Shiga University of Medical Science, 520-2192 Seta Tsukinowa-cho, Otsu, Shiga, Japan. Electronic address: yujit@belle.shiga-med.ac.jp., Nakamura A; Department of Obstetrics and Gynecology, Shiga University of Medical Science, 520-2192 Seta Tsukinowa-cho, Otsu, Shiga, Japan., Amano T; Department of Obstetrics and Gynecology, Shiga University of Medical Science, 520-2192 Seta Tsukinowa-cho, Otsu, Shiga, Japan., Inatomi A; Department of Obstetrics and Gynecology, Shiga University of Medical Science, 520-2192 Seta Tsukinowa-cho, Otsu, Shiga, Japan., Yamanaka H; Department of Obstetrics and Gynecology, Shiga University of Medical Science, 520-2192 Seta Tsukinowa-cho, Otsu, Shiga, Japan., Takahashi A; Department of Obstetrics and Gynecology, Shiga University of Medical Science, 520-2192 Seta Tsukinowa-cho, Otsu, Shiga, Japan., Hanada T; Department of Obstetrics and Gynecology, Shiga University of Medical Science, 520-2192 Seta Tsukinowa-cho, Otsu, Shiga, Japan., Yoneoka Y; Department of Obstetrics and Gynecology, Shiga University of Medical Science, 520-2192 Seta Tsukinowa-cho, Otsu, Shiga, Japan., Tsuji S; Department of Obstetrics and Gynecology, Shiga University of Medical Science, 520-2192 Seta Tsukinowa-cho, Otsu, Shiga, Japan.
Source: Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2026 Mar; Vol. 140, pp. 109153. Date of Electronic Publication: 2025 Dec 27.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Pergamon In Cooperation With The Reproductive Toxicology Center Country of Publication: United States NLM ID: 8803591 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1708 (Electronic) Linking ISSN: 08906238 NLM ISO Abbreviation: Reprod Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1873-1708
DOI:10.1016/j.reprotox.2025.109153