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A mouse model of busulfan-induced ovarian toxicity and evidence for attenuation with mTOR inhibition.

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Title: A mouse model of busulfan-induced ovarian toxicity and evidence for attenuation with mTOR inhibition.
Authors: Deguchi M; Department of Obstetrics and Gynecology, Shiga University of Medical Science, 520-2192 Seta Tsukinowa-cho, Otsu, Shiga, Japan., Tanaka Y; Department of Obstetrics and Gynecology, Shiga University of Medical Science, 520-2192 Seta Tsukinowa-cho, Otsu, Shiga, Japan. Electronic address: yujit@belle.shiga-med.ac.jp., Nakamura A; Department of Obstetrics and Gynecology, Shiga University of Medical Science, 520-2192 Seta Tsukinowa-cho, Otsu, Shiga, Japan., Amano T; Department of Obstetrics and Gynecology, Shiga University of Medical Science, 520-2192 Seta Tsukinowa-cho, Otsu, Shiga, Japan., Inatomi A; Department of Obstetrics and Gynecology, Shiga University of Medical Science, 520-2192 Seta Tsukinowa-cho, Otsu, Shiga, Japan., Yamanaka H; Department of Obstetrics and Gynecology, Shiga University of Medical Science, 520-2192 Seta Tsukinowa-cho, Otsu, Shiga, Japan., Takahashi A; Department of Obstetrics and Gynecology, Shiga University of Medical Science, 520-2192 Seta Tsukinowa-cho, Otsu, Shiga, Japan., Hanada T; Department of Obstetrics and Gynecology, Shiga University of Medical Science, 520-2192 Seta Tsukinowa-cho, Otsu, Shiga, Japan., Yoneoka Y; Department of Obstetrics and Gynecology, Shiga University of Medical Science, 520-2192 Seta Tsukinowa-cho, Otsu, Shiga, Japan., Tsuji S; Department of Obstetrics and Gynecology, Shiga University of Medical Science, 520-2192 Seta Tsukinowa-cho, Otsu, Shiga, Japan.
Source: Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2026 Mar; Vol. 140, pp. 109153. Date of Electronic Publication: 2025 Dec 27.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Pergamon In Cooperation With The Reproductive Toxicology Center Country of Publication: United States NLM ID: 8803591 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1708 (Electronic) Linking ISSN: 08906238 NLM ISO Abbreviation: Reprod Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
An: 41461242
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
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  Data: A mouse model of busulfan-induced ovarian toxicity and evidence for attenuation with mTOR inhibition.
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  Data: <searchLink fieldCode="AU" term="%22Deguchi+M%22">Deguchi M</searchLink>; Department of Obstetrics and Gynecology, Shiga University of Medical Science, 520-2192 Seta Tsukinowa-cho, Otsu, Shiga, Japan.<br /><searchLink fieldCode="AU" term="%22Tanaka+Y%22">Tanaka Y</searchLink>; Department of Obstetrics and Gynecology, Shiga University of Medical Science, 520-2192 Seta Tsukinowa-cho, Otsu, Shiga, Japan. Electronic address: yujit@belle.shiga-med.ac.jp.<br /><searchLink fieldCode="AU" term="%22Nakamura+A%22">Nakamura A</searchLink>; Department of Obstetrics and Gynecology, Shiga University of Medical Science, 520-2192 Seta Tsukinowa-cho, Otsu, Shiga, Japan.<br /><searchLink fieldCode="AU" term="%22Amano+T%22">Amano T</searchLink>; Department of Obstetrics and Gynecology, Shiga University of Medical Science, 520-2192 Seta Tsukinowa-cho, Otsu, Shiga, Japan.<br /><searchLink fieldCode="AU" term="%22Inatomi+A%22">Inatomi A</searchLink>; Department of Obstetrics and Gynecology, Shiga University of Medical Science, 520-2192 Seta Tsukinowa-cho, Otsu, Shiga, Japan.<br /><searchLink fieldCode="AU" term="%22Yamanaka+H%22">Yamanaka H</searchLink>; Department of Obstetrics and Gynecology, Shiga University of Medical Science, 520-2192 Seta Tsukinowa-cho, Otsu, Shiga, Japan.<br /><searchLink fieldCode="AU" term="%22Takahashi+A%22">Takahashi A</searchLink>; Department of Obstetrics and Gynecology, Shiga University of Medical Science, 520-2192 Seta Tsukinowa-cho, Otsu, Shiga, Japan.<br /><searchLink fieldCode="AU" term="%22Hanada+T%22">Hanada T</searchLink>; Department of Obstetrics and Gynecology, Shiga University of Medical Science, 520-2192 Seta Tsukinowa-cho, Otsu, Shiga, Japan.<br /><searchLink fieldCode="AU" term="%22Yoneoka+Y%22">Yoneoka Y</searchLink>; Department of Obstetrics and Gynecology, Shiga University of Medical Science, 520-2192 Seta Tsukinowa-cho, Otsu, Shiga, Japan.<br /><searchLink fieldCode="AU" term="%22Tsuji+S%22">Tsuji S</searchLink>; Department of Obstetrics and Gynecology, Shiga University of Medical Science, 520-2192 Seta Tsukinowa-cho, Otsu, Shiga, Japan.
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  Data: <searchLink fieldCode="JN" term="%228803591%22">Reproductive toxicology (Elmsford, N.Y.)</searchLink> [Reprod Toxicol] 2026 Mar; Vol. 140, pp. 109153. <i>Date of Electronic Publication: </i>2025 Dec 27.
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  Data: Journal Article; Research Support, Non-U.S. Gov't
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Pergamon+In+Cooperation+With+The+Reproductive+Toxicology+Center%22">Pergamon In Cooperation With The Reproductive Toxicology Center </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8803591 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-1708 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2208906238%22">08906238 </searchLink><i>NLM ISO Abbreviation: </i>Reprod Toxicol <i>Subsets: </i>MEDLINE
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              Text: 2026 Mar
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