PCMT1 generates the C-terminal cyclic imide degron on CRBN substrates.
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| Title: | PCMT1 generates the C-terminal cyclic imide degron on CRBN substrates. |
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| Authors: | Zhao Z; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Xu W; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Feng EY; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Cao S; Department of Pharmacology and Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA., Hermoso-López A; Department of Biochemistry and Molecular Biology, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS) and Instituto Universitario de Investigación Neuroquímica (IUIN), Complutense University, Madrid, Spain., Peña-Vega P; Department of Biochemistry and Molecular Biology, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS) and Instituto Universitario de Investigación Neuroquímica (IUIN), Complutense University, Madrid, Spain., Lloyd HC; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Porter AKD; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Guzmán M; Department of Biochemistry and Molecular Biology, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS) and Instituto Universitario de Investigación Neuroquímica (IUIN), Complutense University, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., Zheng N; Department of Pharmacology and Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA., Woo CM; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. cwoo@chemistry.harvard.edu.; Affiliate Member, Broad Institute, Cambridge, MA, USA. cwoo@chemistry.harvard.edu. |
| Source: | Nature chemical biology [Nat Chem Biol] 2026 May; Vol. 22 (5), pp. 802-812. Date of Electronic Publication: 2025 Dec 29. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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