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DF6215, an α-optimized IL-2-Fc fusion, expands immune effectors and drives robust preclinical anti-tumor activity.

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Title: DF6215, an α-optimized IL-2-Fc fusion, expands immune effectors and drives robust preclinical anti-tumor activity.
Authors: Stockmann AP; Dragonfly Therapeutics, Inc., Waltham, MA 02451, USA., Vincent S; Dragonfly Therapeutics, Inc., Waltham, MA 02451, USA., Herschelman L; Dragonfly Therapeutics, Inc., Waltham, MA 02451, USA., Huang CS; Dragonfly Therapeutics, Inc., Waltham, MA 02451, USA., Ma J; Dragonfly Therapeutics, Inc., Waltham, MA 02451, USA., Fallon D; Dragonfly Therapeutics, Inc., Waltham, MA 02451, USA., Kirby P; Dragonfly Therapeutics, Inc., Waltham, MA 02451, USA., Gutierrez E; Dragonfly Therapeutics, Inc., Waltham, MA 02451, USA., Talbot D; Dragonfly Therapeutics, Inc., Waltham, MA 02451, USA., Hicks SW; Dragonfly Therapeutics, Inc., Waltham, MA 02451, USA., Wagtmann N; Dragonfly Therapeutics, Inc., Waltham, MA 02451, USA., Cheung AF; Dragonfly Therapeutics, Inc., Waltham, MA 02451, USA. Electronic address: ann.cheung@dragonflytx.com.
Source: Cell reports. Medicine [Cell Rep Med] 2026 Jan 20; Vol. 7 (1), pp. 102518. Date of Electronic Publication: 2025 Dec 29.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: DF6215, an α-optimized IL-2-Fc fusion, expands immune effectors and drives robust preclinical anti-tumor activity.
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  Data: <searchLink fieldCode="AU" term="%22Stockmann+AP%22">Stockmann AP</searchLink>; Dragonfly Therapeutics, Inc., Waltham, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Vincent+S%22">Vincent S</searchLink>; Dragonfly Therapeutics, Inc., Waltham, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Herschelman+L%22">Herschelman L</searchLink>; Dragonfly Therapeutics, Inc., Waltham, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Huang+CS%22">Huang CS</searchLink>; Dragonfly Therapeutics, Inc., Waltham, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Ma+J%22">Ma J</searchLink>; Dragonfly Therapeutics, Inc., Waltham, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Fallon+D%22">Fallon D</searchLink>; Dragonfly Therapeutics, Inc., Waltham, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Kirby+P%22">Kirby P</searchLink>; Dragonfly Therapeutics, Inc., Waltham, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Gutierrez+E%22">Gutierrez E</searchLink>; Dragonfly Therapeutics, Inc., Waltham, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Talbot+D%22">Talbot D</searchLink>; Dragonfly Therapeutics, Inc., Waltham, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Hicks+SW%22">Hicks SW</searchLink>; Dragonfly Therapeutics, Inc., Waltham, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Wagtmann+N%22">Wagtmann N</searchLink>; Dragonfly Therapeutics, Inc., Waltham, MA 02451, USA.<br /><searchLink fieldCode="AU" term="%22Cheung+AF%22">Cheung AF</searchLink>; Dragonfly Therapeutics, Inc., Waltham, MA 02451, USA. Electronic address: ann.cheung@dragonflytx.com.
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  Data: <searchLink fieldCode="JN" term="%22101766894%22">Cell reports. Medicine</searchLink> [Cell Rep Med] 2026 Jan 20; Vol. 7 (1), pp. 102518. <i>Date of Electronic Publication: </i>2025 Dec 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101766894 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2666-3791 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226663791%22">26663791 </searchLink><i>NLM ISO Abbreviation: </i>Cell Rep Med <i>Subsets: </i>MEDLINE
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              Text: 2026 Jan 20
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