Early start of opicapone in Parkinson's disease: evidence from a pooled analysis of phase 3 trials for sustained benefit in patients with recent onset of motor fluctuations.

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Title: Early start of opicapone in Parkinson's disease: evidence from a pooled analysis of phase 3 trials for sustained benefit in patients with recent onset of motor fluctuations.
Authors: Ferreira JJ; Laboratory of Clinical Pharmacology and Therapeutics, Faculdade de Medicina, Universidade Lisboa, Lisbon, Portugal.; CNS - Campus Neurológico, Torres Vedras, Portugal., Stocchi F; Institute for Research and Medical Care IRCCS San Raffaele, Roma, Italy.; San Raffaele University, Rome, Italy., Antonini A; Neurodegenerative Disease Unit, Centre for Rare Neurological Diseases (ERN-RND), Department of Neuroscience, University of Padova, Padova, Italy.; IRCCS San Camillo, Venice, Italy., Rascol O; NS-Park Network, Toulouse, France.; Department of Clinical Pharmacology and Neurosciences, Toulouse Parkinson Expert Centre, Toulouse NeuroToul Center of Excellence in Neurodegeneration (COEN), French NS-Park/F-CRIN Network, University of Toulouse 3, CHU of Toulouse, INSERM, Toulouse, France., Ebersbach G; Movement Disorders Hospital, Beelitz-Heilstätten, Beelitz, Germany., Kulisevsky J; Movement Disorders Unit, Neurology Department, Sant Pau Hospital, Barcelona, Spain.; Biomedical Research Institute (IIB-Sant Pau), Barcelona, Catalunya, Spain.; Center for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Fonseca MM; BIAL - R&D Investments, S.A., Porto, Portugal., Ramos D; BIAL - Portela & Ca, S.A., Coronado, Portugal., Rocha JF; BIAL - Portela & Ca, S.A., Coronado, Portugal., Brigas HC; BIAL - Portela & Ca, S.A., Coronado, Portugal., Holenz J; BIAL - Portela & Ca, S.A., Coronado, Portugal., Poewe W; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Source: Frontiers in neurology [Front Neurol] 2025 Dec 15; Vol. 16, pp. 1715748. Date of Electronic Publication: 2025 Dec 15 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101546899 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2295 (Print) Linking ISSN: 16642295 NLM ISO Abbreviation: Front Neurol Subsets: PubMed not MEDLINE
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  Data: Early start of opicapone in Parkinson's disease: evidence from a pooled analysis of phase 3 trials for sustained benefit in patients with recent onset of motor fluctuations.
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  Data: <searchLink fieldCode="AU" term="%22Ferreira+JJ%22">Ferreira JJ</searchLink>; Laboratory of Clinical Pharmacology and Therapeutics, Faculdade de Medicina, Universidade Lisboa, Lisbon, Portugal.; CNS - Campus Neurológico, Torres Vedras, Portugal.<br /><searchLink fieldCode="AU" term="%22Stocchi+F%22">Stocchi F</searchLink>; Institute for Research and Medical Care IRCCS San Raffaele, Roma, Italy.; San Raffaele University, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Antonini+A%22">Antonini A</searchLink>; Neurodegenerative Disease Unit, Centre for Rare Neurological Diseases (ERN-RND), Department of Neuroscience, University of Padova, Padova, Italy.; IRCCS San Camillo, Venice, Italy.<br /><searchLink fieldCode="AU" term="%22Rascol+O%22">Rascol O</searchLink>; NS-Park Network, Toulouse, France.; Department of Clinical Pharmacology and Neurosciences, Toulouse Parkinson Expert Centre, Toulouse NeuroToul Center of Excellence in Neurodegeneration (COEN), French NS-Park/F-CRIN Network, University of Toulouse 3, CHU of Toulouse, INSERM, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Ebersbach+G%22">Ebersbach G</searchLink>; Movement Disorders Hospital, Beelitz-Heilstätten, Beelitz, Germany.<br /><searchLink fieldCode="AU" term="%22Kulisevsky+J%22">Kulisevsky J</searchLink>; Movement Disorders Unit, Neurology Department, Sant Pau Hospital, Barcelona, Spain.; Biomedical Research Institute (IIB-Sant Pau), Barcelona, Catalunya, Spain.; Center for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Fonseca+MM%22">Fonseca MM</searchLink>; BIAL - R&D Investments, S.A., Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Ramos+D%22">Ramos D</searchLink>; BIAL - Portela & Ca, S.A., Coronado, Portugal.<br /><searchLink fieldCode="AU" term="%22Rocha+JF%22">Rocha JF</searchLink>; BIAL - Portela & Ca, S.A., Coronado, Portugal.<br /><searchLink fieldCode="AU" term="%22Brigas+HC%22">Brigas HC</searchLink>; BIAL - Portela & Ca, S.A., Coronado, Portugal.<br /><searchLink fieldCode="AU" term="%22Holenz+J%22">Holenz J</searchLink>; BIAL - Portela & Ca, S.A., Coronado, Portugal.<br /><searchLink fieldCode="AU" term="%22Poewe+W%22">Poewe W</searchLink>; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
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  Data: <searchLink fieldCode="JN" term="%22101546899%22">Frontiers in neurology</searchLink> [Front Neurol] 2025 Dec 15; Vol. 16, pp. 1715748. <i>Date of Electronic Publication: </i>2025 Dec 15 (<i>Print Publication: </i>2025).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation%22">Frontiers Research Foundation </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101546899 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>1664-2295 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216642295%22">16642295 </searchLink><i>NLM ISO Abbreviation: </i>Front Neurol <i>Subsets: </i>PubMed not MEDLINE
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