Molecular and phenotypic blueprint of human hematopoiesis links proliferation stress to stem cell aging.

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Title: Molecular and phenotypic blueprint of human hematopoiesis links proliferation stress to stem cell aging.
Authors: Lettera E; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS Ospedale San Raffaele , Milan, Italy.; Università Vita-Salute San Raffaele , Milan, Italy., Basso-Ricci L; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS Ospedale San Raffaele , Milan, Italy., Carsana E; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS Ospedale San Raffaele , Milan, Italy., Giannetti K; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS Ospedale San Raffaele , Milan, Italy., Tavella T; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS Ospedale San Raffaele , Milan, Italy., Seffin L; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS Ospedale San Raffaele , Milan, Italy.; Università Vita-Salute San Raffaele , Milan, Italy., Farina G; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS Ospedale San Raffaele , Milan, Italy., Gualandi N; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS Ospedale San Raffaele , Milan, Italy., Quaranta P; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS Ospedale San Raffaele , Milan, Italy.; Università Vita-Salute San Raffaele , Milan, Italy., Lo Furno E; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS Ospedale San Raffaele , Milan, Italy., Pacini G; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS Ospedale San Raffaele , Milan, Italy., Della Volpe L; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS Ospedale San Raffaele , Milan, Italy., Kaufmann KB; University Health Network, Princess Margaret Cancer Centre , Toronto, Canada., Garcia-Prat L; University Health Network, Princess Margaret Cancer Centre , Toronto, Canada., Hernandez RJ; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS Ospedale San Raffaele , Milan, Italy., Murison A; University Health Network, Princess Margaret Cancer Centre , Toronto, Canada., Aguilar-Navarro AG; University Health Network, Princess Margaret Cancer Centre , Toronto, Canada.; Unidad de Investigación Médica en Enfermedades Oncológicas, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social , Mexico City, Mexico., Beretta S; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS Ospedale San Raffaele , Milan, Italy., Conti A; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS Ospedale San Raffaele , Milan, Italy., Flores-Figueroa E; University Health Network, Princess Margaret Cancer Centre , Toronto, Canada.; Unidad de Investigación Médica en Enfermedades Oncológicas, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social , Mexico City, Mexico., Ometti M; Department of Orthopedic Surgery and Traumatology, IRCCS Ospedale San Raffaele, Milan, Italy., Merelli I; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS Ospedale San Raffaele , Milan, Italy., Aiuti A; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS Ospedale San Raffaele , Milan, Italy.; Università Vita-Salute San Raffaele , Milan, Italy.; Pediatric Immunohematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute , Milan, Italy., Xie SZ; University Health Network, Princess Margaret Cancer Centre , Toronto, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Canada., Scala S; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS Ospedale San Raffaele , Milan, Italy., Di Micco R; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS Ospedale San Raffaele , Milan, Italy.; University School of Advanced Studies IUSS , Pavia, Italy.
Source: The Journal of experimental medicine [J Exp Med] 2026 Feb 02; Vol. 223 (2). Date of Electronic Publication: 2025 Dec 30.
Publication Type: Journal Article
Journal Info: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1540-9538
DOI:10.1084/jem.20251805