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Native C3 is activated without proteolytic cleavage by transformation to C3(H2O) on phospholipid-scrambled cell membranes.

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Title: Native C3 is activated without proteolytic cleavage by transformation to C3(H2O) on phospholipid-scrambled cell membranes.
Authors: Eikrem D; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden., Manivel VA; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden., Whittaker J; Department of Molecular Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden., Hamad OA; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden., Mohlin C; Linnaeus Centre for Biomaterials Chemistry, Linnaeus University, Kalmar, Sweden., Adler A; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden., Dührkop C; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden., Ebert R; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden., Teramura Y; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.; Cellular and Molecular Biotechnology Research Institute (CMB), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan.; Master's/Doctoral Program in Life Science Innovation (T-LSI), University of Tsukuba, Tsukuba, Ibaraki, Japan., Ekdahl KN; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.; Linnaeus Centre for Biomaterials Chemistry, Linnaeus University, Kalmar, Sweden., Fromell K; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden., Nilsson B; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Source: Frontiers in immunology [Front Immunol] 2025 Dec 16; Vol. 16, pp. 1729532. Date of Electronic Publication: 2025 Dec 16 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Native C3 is activated without proteolytic cleavage by transformation to C3(H<subscript>2</subscript>O) on phospholipid-scrambled cell membranes.
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  Data: <searchLink fieldCode="AU" term="%22Eikrem+D%22">Eikrem D</searchLink>; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Manivel+VA%22">Manivel VA</searchLink>; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Whittaker+J%22">Whittaker J</searchLink>; Department of Molecular Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Hamad+OA%22">Hamad OA</searchLink>; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Mohlin+C%22">Mohlin C</searchLink>; Linnaeus Centre for Biomaterials Chemistry, Linnaeus University, Kalmar, Sweden.<br /><searchLink fieldCode="AU" term="%22Adler+A%22">Adler A</searchLink>; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Dührkop+C%22">Dührkop C</searchLink>; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Ebert+R%22">Ebert R</searchLink>; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Teramura+Y%22">Teramura Y</searchLink>; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.; Cellular and Molecular Biotechnology Research Institute (CMB), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan.; Master's/Doctoral Program in Life Science Innovation (T-LSI), University of Tsukuba, Tsukuba, Ibaraki, Japan.<br /><searchLink fieldCode="AU" term="%22Ekdahl+KN%22">Ekdahl KN</searchLink>; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.; Linnaeus Centre for Biomaterials Chemistry, Linnaeus University, Kalmar, Sweden.<br /><searchLink fieldCode="AU" term="%22Fromell+K%22">Fromell K</searchLink>; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Nilsson+B%22">Nilsson B</searchLink>; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2025 Dec 16; Vol. 16, pp. 1729532. <i>Date of Electronic Publication: </i>2025 Dec 16 (<i>Print Publication: </i>2025).
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