Lymphotoxin-dependent elevated meningeal CXCL13:BAFF ratios drive gray matter injury.

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Title: Lymphotoxin-dependent elevated meningeal CXCL13:BAFF ratios drive gray matter injury.
Authors: Naouar I; Department of Immunology, University of Toronto, Toronto, Ontario, Canada., Pangan A; Department of Immunology, University of Toronto, Toronto, Ontario, Canada., Zuo M; Department of Immunology, University of Toronto, Toronto, Ontario, Canada., Raza SA; Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Champagne-Jorgensen K; Department of Immunology, University of Toronto, Toronto, Ontario, Canada., Patel J; Department of Immunology, University of Toronto, Toronto, Ontario, Canada., Wang A; Department of Immunology, University of Toronto, Toronto, Ontario, Canada., Pu A; Department of Immunology, University of Toronto, Toronto, Ontario, Canada., Ward L; Department of Immunology, University of Toronto, Toronto, Ontario, Canada., Ahn JSY; Department of Immunology, University of Toronto, Toronto, Ontario, Canada., Sayeed FN; Department of Immunology, University of Toronto, Toronto, Ontario, Canada., Zhu J; Department of Immunology, University of Toronto, Toronto, Ontario, Canada., Pössnecker E; Department of Neurology, University Hospital of Basel and University of Basel, Basel, Switzerland.; Departments of Biomedicine and Clinical Research, University Hospital of Basel and University of Basel, Basel, Switzerland.; Research Center for Clinical Neuroimmunology and Neuroscience Basel, University Hospital of Basel and University of Basel, Basel, Switzerland.; Center of Neurology, Department of Neuroimmunology, University Hospital and University Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases, Bonn, Germany., Spring S; Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada., Sled JG; Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada., Cenni B; Novartis BioMedical Research, Basel, Switzerland., Nuesslein-Hildesheim B; Novartis BioMedical Research, Basel, Switzerland., Browning JL; Department of Virology, Immunology and Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA., Pröbstel AK; Department of Neurology, University Hospital of Basel and University of Basel, Basel, Switzerland.; Departments of Biomedicine and Clinical Research, University Hospital of Basel and University of Basel, Basel, Switzerland.; Research Center for Clinical Neuroimmunology and Neuroscience Basel, University Hospital of Basel and University of Basel, Basel, Switzerland.; Center of Neurology, Department of Neuroimmunology, University Hospital and University Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases, Bonn, Germany., Reich DS; Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Gommerman JL; Department of Immunology, University of Toronto, Toronto, Ontario, Canada. jen.gommerman@utoronto.ca., Ramaglia V; Department of Immunology, University of Toronto, Toronto, Ontario, Canada. valeria.ramaglia@uhn.ca.; Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada. valeria.ramaglia@uhn.ca.
Source: Nature immunology [Nat Immunol] 2026 Jan; Vol. 27 (1), pp. 48-60. Date of Electronic Publication: 2026 Jan 02.
Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1529-2916
DOI:10.1038/s41590-025-02359-5